Spitomin

Roman name

Spitomin #

The composition and the form of

1 tablet contains buspirona hydrochloride 5 or 10 mg; blistere in 10 pcs. , in box 6 blisters.

Of drugs

Anxiolytic, antidepressant. Yes blocks presinapticalkie dofaminove receptors and increases the speed of an dofamine secondary neuronal brain selectively initiates (partial agonist) serotoninove subtype receptors 1A (5-NT1A).

Pharmacokinetics

Once inside quickly and completely absorbed from the digestive tract. Bioavailability to 90%. Linking plasma protein is about 95%. The effect has been reflected in 7-14 days and reaches its maximum, through four weeks. Metabolised in the liver by gidrauxilirovania and glukuronirovania to education 1-пиримидинилпиперази на. Report the news, largely in the form of metabolites (1% in unmodified form) and through blood (18-38%). T_1/2 substance 2,4-2,7-hour T_1/2 metabolita 4.8 hours The agent can enter the breast milk.

Farmakodinamika

Has no adverse effects on psychomotor functions, it is tolerance, drug dependence and withdrawal symptoms. Not potenziruet of alcohol.

Indications

Generalizovannoe disturbing disorder, panic disorder syndrome vegetative dystonia, alcohol syndrome symptoms (supplementary therapy), mild depression (secondary treatment).

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivit 218 y, severe violations of the kidneys and liver, glaucoma, male gravis, pregnancy, breast-feeding.

Side-Effects

From the nervous system and sensory organs : headache, nervousness, sleep disturbance, it is very rarely ekstrapiramidnye Rasstroistva.so part of the intestine : reduced appetite, nausea, vomiting, diarrhoea.

Patient interaction

When combined with MAO inhibitors may develop gipertoniceski kriza.

Overdosing

Symptoms : nausea, and vomiting, etc. gastrointestinale disorders, dizziness, unconsciousness, Sonlivosti.lechenie : washing stomach, the appointment of activated carbon symptomatic therapy. Dialysis ineffective.

Precautions

Very caution should be appointed at the same time as neiroleptikami, antidepressants, cardiac glycosides, antigipertenzivei means antidiabeticakimi drugs, oral contraceptives. In kidney and liver failure mild, cirrhosis of the liver should be appointed under the close supervision of a doctor, usually in smaller doses.

Dosing and Administration

Inside. Dosage is individually. The recommended initial dose, 5 mg three times daily, when necessary, may be increased by 5 mg every 2-3 days. The average daily intake of 20 to 30-mg. The maximum single dose of 30 mg daily to 60 mg.

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