Stimuloton

Roman name

Stimuloton #

The composition and the form of

1 tablet coated liner sertralina contains 50 mg; in a contour acheikova packing 10 pcs. , in a cardboard unit 1, 2 or 3 of the package.

Of drugs

Antidepressive. Yes blocking reverse takeover serotonin in the presinapticalkie neuronal brain.

Pharmacokinetics

Slowly absorbed from the digestive tract. C_max determined through 4,5-8,4 hours Linking plasma protein is 98%. The volume of 20 l / kg Metabolised in the liver to education metabolita active. T_1/2 - 22-36 hour methylated gomologa - 62-104 hours Secretiruetsa in breast milk. Not to be removed by dialysis.

Farmakodinamika

Antidepressant effect is manifested through the two weeks after the start of treatment, and reaches its maximum six weeks.

Indications

Depression (including relapse prevention) обсессивно-компульси��ные disorder, panic disorder (including both agorafobiei).

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, unstable epilepsy, the joint application with MAO inhibitors, or triptofanom fenfluraminom, pregnancy, breast-feeding, age up to six years.

Side-Effects

From the nervous system and sensory organs : weakness, drowsiness / insomnia, dizziness, tremor, the obsession or gipomaniakalnogo condition; Violations Zrenia.so part of the intestine : a lack of appetite, dry mouth, nausea, vomiting, flatulence, Diarea.so the urogenital system : never disorders, diminished libido, human menstrual Zikla.so the skin : skin rashes, multiformnaya erythema (rarely). Other : giperprolaktinemia, galactorea, increased sweating, increased activity transaminaz in whey, obratimaya giponatriemia, lifting syndrome (hypothetical and parestesia, depression, hallucinations, aggressive reaction, agitation).

Patient interaction

Is cumulation (blocking biotransformatia) H_1 -gistaminoblokatorov (astemizol, terfenadin, cizaprid). Increases free fraction of plasma (excluding from the protein) H_2 -blokatorov, tricyclic antidepressants, derivatives sulfanilmocevina, anxiety, racumin, digoxin. Decreases T_1/2 antipirina increases the concentration desipramina (with the long-term use). Zimetidin lowers klirens sertralina.

Overdosing

Symptoms : mood, anxiety, dizziness, increased inhibition, Tahikardia.lechenie : appointment of absorbent (activated carbon), the maintenance of vital functions.

Precautions

During therapy requires continuous medical monitoring of patients with depression, with a high risk of suicide attempts. When expressed human liver to reduce the dose or an increase in the interval between meals preparation. When coupled with a LAN affecting serotoninergicescuu transfer, should proceed with caution. Joint appointment MAO inhibitors contraindicated because increased risk of serotoninovogo syndrome (hyperthermia, mioclonus, rigidity, altered mental status, etc.). When coupled with the use of coumarin derivatives, it was necessary to monitor (at the beginning of treatment and after the drug) protrotrombinovoe time. It is a caution during the drivers of vehicles and people skills relate to the high concentration of attention. During treatment is not recommended acceptance of alcohol and wrathful beverages.

Dosing and Administration

Inside, once daily. Depression and обссесивно-компульси��ные disorders -- 50 mg once a day; panic disorder, the initial dose of 25 mg. In the absence of effective dose can be gradually increased to 50 mg per week until the maximum daily 200 mg. To achieve economies of a 2-4 weeks, in patients with обсессивно-компульси��ными disorders to 8-12 Weeks In the future, the minimum therapeutic dose as a supporter.

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