Tianeptine

Chemical name

7-[(3-Хлор-6,11-дигидро-6-м��тилдибензо[c,f][1,2]тиаз��пин-11-ил)амино]гептан��вой acid S S-dioksid

Gross

C21-H25-Cl-N2-O4-S

Of drugs

Drugs, the antidepressant, anxiolytic. Its middle of the pushing and laboratory antidepressants. Increases speed reverse takeover serotonin neurons cortex brain and gippocampa increases spontaneous activity pyramid gippocampa cells and accelerates their recovery after building functional braking. Impact sense of melancholy, improves mood, eliminates motor block, add to the overall tone, normalizes the behavior (for instance, the withdrawal). Is disappearance somatic complaints arising from the anxiety and mood changes. It affects the cardiovascular system, sleep, the reaction rate, the parasympathetic nervous system, it is Privkania.bystro and completely absorbed in the digestive tract. The blood is associated with a protein of 94%. Easily passes through gistogematicalkie barriers, including GEB through. The liver is beta-okisleniu and N-demetilirovaniu. T_1/2-2.5 h, the elderly and in patients with renal insufficiency, 3.5 hours Report kidney (8% in an unmodified form).

Indications

Depression and depressive state of any etiology, including nervous and reactive, тревожно-депрессивны�� state with somatic complaints (particularly in the gastrointestinal pathology), alcoholism (the withdrawal).

Contraindications

Pregnancy, breast-feeding (for the period of treatment must be abandoned), childhood and adolescence (15 years) age.

Side-Effects

Dizziness, headache, insomnia / drowsiness, and the slowdown in the rate of reaction, nightmares, fatigue, fear, tremor, tachycardia, arrythmia, stenocardia, dry mouth, anorexia, gastralgia, nausea, vomiting, constipation, flatulence, a burning sensation, larynx spasm, difficulty in breathing, pain (muscle in the lower back).

Patient interaction

Incompatible with MAO inhibitors (possibly the collapse, sudden increases AD hyperthermia, convulsions and death).

Precautions

At the beginning of treatment, continuous monitoring of the sick because of the growing likelihood of suicide attempts. It is for 24 to 48 hours to lift the tianeptin operation under anaesthesia. Finished treatment phase (7-14 days) lower daily doses. When active sports activities requiring greater attention and rapid mental and motor reactions, it is recommended that patients exempt from the work at the time of therapy. Upon receiving the MAO inhibitors for tianeptin a break in two weeks and, as his replacement MAO inhibitors break in 24 hours

Dosing and Administration

Inside, the food on one table. 3 times a day (persons over 70 years of age and patients with renal insufficiency, twice a day).

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