Trazodone

Chemical name

2-[3-[4-(3-Хлорфенил)-1-пип��разинил]пропил]-1,2,4-тр иазоло[4,3-a]пиридин-3(2Н) -он (as hydrochloride)

Gross

C19-H22-Cl-N5-O

Characteristics

The white crystalline powder and odourless, well-soluble in water.

Of drugs

Drugs, the antidepressant, sedative. Ingibiruet selective serotonin hostage sinaptosomami brain and changes potenziruet behavioral reactions inducyruemye serotonin precursor 5-gidroksitriptofanom, blocks альфа-адренорецептор��.Быстро and is extracted from the blood. Time to C_max is about 1 hour (it increases after meals). Passes through gistogematicalkie barriers, including GEB. Penetrates into tissue and exosecret (elixirs, saliva, milk, etc.). The liver is transformations. Eliminations has two-phase nature. T_1/2 first phase is 3-6 hour later 5-9 hours; Can be granted. Excreted (along with metabolites) is the мочой.Терапевтически�� effects half the patients are between 3 to 7 days, the 3 / 4 at the end of the second week and the 1 / 4-2-4 weeks. Antidepressive (timolepticescoe) The combined with anksioliticski and tranquilizing (effective when expressed dismay and severe insomnia).

Indications

Depressive of organic and psihogennogo origin including to the concerns Anxiety, when at least four of the signs of depression : changes in appetite, sleep, psychomotor ajitation or block, the reduction of interest to business as usual, demotion sexual initiative fatigue, a sense of guilt, slow thinking, the deterioration of concentration, suicidal thoughts; bulimia, kleptomania, preventing migraines, anxiety, phobias (including agorafobia) acute alcohol withdrawal syndrome, benzodiazepinova dependence Then for.

Contraindications

Hypersensitivity, the initial period after myocardial infarction, violations of the heart rhythm expressed disorders liver and kidneys, pregnancy, breast-feeding (at the time of treatment deleted).

Side-Effects

Changing view, eye irritation, zalojennosti nose, constipation, diarrhea, dry and bitterness in the mouth, nausea, vomiting, dizziness, drowsiness, fatigue, headache, mialgii, discoordination, parestesia, disorientation, shading consciousness, tremor, the rhythm of the heart and conductivity, aetiology, fibrillace predserdy Arterial gipotenzia elements Orthostatic Hypotension and sincopalnami states lakopenia, neutropenia (usually minor), priapizm, allergic swelling, allergic skin reactions.

Patient interaction

Changes effect racumin (increases or decreases), potenziruet effect preparations oppressive central nervous system, including barbiturates, alcohol. Antigipertenzivee to increase the risk Orthostatic Hypotension. Decreases hypotension caused Clonidine. Increases plasma concentration of digoxin and fenitoina.

Overdosing

Symptoms : nausea, drowsiness, priapizm, stops breathing, seizures epileptiformnye, changes in the EKG, and increases weighting by Reackzi.lechenie : washing stomach and big diurez to speed off, the maintenance of vital functions.

Precautions

In appointing immediately after the MAO inhibitors or with them, a therapy with extreme caution. Not recommended combined with elektroshokami. Patients male should prevent the need for immediate treatment to a doctor (end trazodona reception), with the appearance of the long and inadequate penis. Because the illness can persist suicidal tendencies, the patient should prescribe medication in the minimum required quantities. The caution (at constant monitoring of heart rhythm) Designate to heart diseases, hypertension (because of the increased risks gipotenziveh reactions may require direct antigipertenziveh doses of drugs). The operation under general anaesthetic obligatory early lifting trazodon. During the period of treatment is not recommended reception alcohol. Be wary of during the drivers of vehicles and people skills relate to the high concentration of attention.

Dosing and Administration

Inside, the food. As antidepressant -- 50 mg three times a day, and then, depending on the type and severity of depression gradually dose (50 mg every 3-4 days) add up to 300 to 500 mg / day (no more than 600 mg); Supporting dose also selected individually. As anxiolitika-to 25 mg three times daily. In / in and / m-50 mg to Then.

Directory → Neurotropic funds → 24.2.1 → Trazodone