Memantin

Chemical name

3,5-Диметил-1-адамантан��мин

Gross

C12-H21-N

Characteristics

Derived amantadina.

Of drugs

The drugs-neiroproteguoe, antispasticescoe, противопаркинсоничес кое. Is competitive antagonist glutamatnah N-metil-d-aspartat (NMDA) receptors inhibits glutamatergicescuu neirotransmissiu and progressive neurological processes has neiromodulirutee действие.Способствуе�� Normalization of mental activity (improves memory and the ability to focus, reduces fatigue, the symptoms of depression, etc.) and the correction of propulsion.

Indications

Violation of the CNS mild (reducing memory and the ability to concentrate, loss of interest in activities, rapid fatigability, with the ability to serve themselves, dementia); Spasticity skeletal muscle, the motor in the event of a malfunction brain and spinal structures (head injuries, including early childhood, multiple sclerosis, paraplegia, stroke), Parkinson's disease, parkinsonism.

Restrictions on the use of

Epilepsy, thyrotoxicosis, pregnancy, breast-feeding.

Pregnancy and lactation

Be wary of pregnancy (sufficient experience use during pregnancy is not), and breast milk (no data on the penetration of breast milk).

Contraindications

Hypersensitivity, sputannosti consciousness expressed by human liver and kidneys.

Side-Effects

From the nervous system and sensory organs : dizziness, or domestic dwigatelnoe concern, anxiety, fatigue, increased vnutricerepnogo Davlenia.prochie : nausea.

Patient interaction

Do the barbiturates, Neuroleptics, antiholinergicakih of levodopa, agonists dofaminergicakih receptors (bromokriptin etc.), amantadina. You can change the effect dantrolena and baklofena.

Precautions

Be wary of during the drivers of vehicles and people skills relate to the high concentration of attention.

Dosing and Administration

Inside, at the time of delivery. Adults : initial dose of 5 mg / day, if necessary dose can be increased weekly by 5 mg supporting dose 10 to 20 mg / day (up to 60 mg / day). Children - 0.5 mg / kg / day, or at the rate of one ounce per 1 kg of body weight.

Literature

Gavrilova SI, GA Zharikov Treatment for the disease Альцгеймера//Психиатр ия and psihofarmakoterapia .- 2001 .- T. 3-N 2 - C. 45-48.

Directory → Neurotropic funds → Other means of neurotropic → Memantin