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The groupLocal anaesthetics reduced or completely suppress anxiety sensitive nerve endings in the nose scratched, skin and other tissues in direct contact. Depending on the mode of local anestetika between terminal diseases (anestetik be on the surface, where it blocks the sensitive nerves), infiltration (water anestetika consistently "permeate" the skin and deep tissues) provodnikovuyu (anestetik impose's nerves, resulting in a block of the institute on the nerve fibres) spinnomozgovu hour (anestetik impose subarahnoidalno).
The substance, which found mestnoanestezirutuyu activity was produce cocaine. Because of the high toxicity, it is now little used. In modern anesthesiology is the use of a variety of synthetic local anaesthetics. These include anestein, novocaine, trimekain, dikain (mainly ophthalmology practice), piromekain, lidocaine. Recently, a dlitionodactute local anaesthetics (bupivacaine, etc.).
Use of drugs depends on their pharmacological and the physico-chemical properties : anestein as unreduced substance applies only superficially. Soluble drugs used for different types of local anaesthesia.
Some local anaesthetics have antiaritmicescoy activity. Lots is relatively widely used in certain types of arrhythmias. For the same purpose trimekain used.