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ArticaineChemical name4-Метил-3-[[1-оксо-2-(проп��ламино)пропил]амино]-2 -тиофенкарбоновой acid methyl ester (as hydrochloride)GrossC13-H20-N2-O3-SCharacteristicsLocal anestetik from group Amidov.bely or white with kremovatam white crystalline powder. Rat in the water and alcohol.Of drugsThe drugs - местноанестезирующее . The tissues (in alkalescent Programme) is hydrolysis and release base has lipofilnami properties and easily penetrating through the membrane inside nerve fibres. Ionize (because of the lower pH), and transformed into cation. Interacts with the receptors, ingibiruet entrance of sodium ions in the cell depolarization phase, and blocks the momentum from the nerve in Voloknu.pri / m introduction C_max achieved through 20-40 minutes. T_1/2 about 40 minutes. Biotransformiroetsa in the liver. Write mainly kidneys (about 60%) Duration of anesthesia at 60 min and 180 min, with the addition of vazokonstrictorov. The acid environment effect is diminished.IndicationsLocal anaesthesia : infiltrazionnaya, provodnikova (spinnomozgova, lumbar).ContraindicationsHypersensitivity, bronchial asthma, severe violations of heart rhythm, zakratougolnaya glaucoma.Side-EffectsHeadache, produced in the eyes, diplopia, jerkiness muscles of consciousness, allergic reaction (swelling, and redness at the site of introduction, urticaria, swelling Kwinke, anaphylactic shock).Patient interactionEffect enhance and prolong vazokonstrictora.Dosing and AdministrationDropped. Dose for adults up to 7 mg / kg, for children up to 5 mg / kgSee also |
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