Markain

Roman name

Marcaine

The composition and the form of

1 ml solution for injection contains bupiwakaina hydrochloride 2.5 and 5 mg; Patients in the 20 ml, in a Box 5 pcs. (Marcain); or 5 mg; in the sealed to 4 ml, in a box or contour acheikova package 5 pcs. (Marcain Spinal, Marcain Spinal Hawi). Marcain Spinal also contains 8 mg / ml sodium chloride and Marcain Spinal Hawi - 80 mg / ml dekstrozy monogidrata.1 ml solution for injection-bupiwakaina hydrochloride 2.5, or 5 mg and adrenalin 5 µ g (Marcain adrenaline); Patients in the 20 ml, in a Box 5 pcs.

Pharmacokinetics

Lipofilen; The distribution among the oil / water is 27.5. The concentration of plasma - 0.4 µ g / ml for every imposed 100 mg. Destroyed in the liver, the main metabolites - 2,6-pipekolixidin and its derivatives. The distribution-73 litres T_1/2 2.7 hours The liver excretion 0.4. Cl - 0.58 l / min. 6% return in an unaltered form.

Pregnancy and lactation

Passes through the placental barrier, partially penetrates into breast milk.

Contraindications

Гиперчувствительност ь to the local anestetikam amide type. Contraindications for the / in anaesthesia at Bir.

Patient interaction

Do toxic effect other local anesthetics or similar with them on the same Preparatov.pri adrenalinsoderjath application solutions with tricyclic antidepressants, necardioselektivei blokatorami, drugs ergotaminovogo stimulants, as well as in conjunction with the general anaesthetic drugs galotana type of potential long гипертензии.Фенотиаз��ны butirofenona and reduce pressornyi effect contests.

Overdosing

Bupivacaine appointed in high doses, can have toxic effects on the central nervous system and cardiovascular system. This also happens in the event of accidental vnutrisosudistom introduction. However, the dose of medication required for spinal anaesthesia, so low (20% or less of what is needed to relieve epiduralna) that the reaction of acute intoxication unlikely.

Precautions

There is evidence of cardiac arrest or death if used for epiduralna anaesthesia or peripheral blockade. The retrobulbarna anaesthesia in the event of accidental ingestion arachnoidal space can cause respiratory. To use caution in patients with partial or complete heart blockade progressive liver disease, heavy impaired kidneys, weakened by the sick and elderly. Local anaesthetics containing adrenaline used with caution in people with severe conditions, which could worsen as a result of sports, as well as in carrying out closures in the areas krovosnabjaemah arteries final type or disturbed krovosnabjeniem. Avoid vnutrisosudistogo application.

Dosing and Administration

Users or infuzionno dose depends on the type of blockade.

Storage conditions

List B. The temperature is not above 25 ° C. Do not freeze.

Shelf life

3 years

The registration

014085/01-2002 (Ann.2004)

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