Procaine

Chemical name

2-(Диэтиламино)этил-4-а��инобензоат (as hydrochloride)

Gross

C13-H20-N2-O2

Characteristics

Clear crystals or white crystalline powder odourless. Very easily soluble in water, easily soluble in alcohol.

Of drugs

The drugs - местноанестезирующее . Violate generation and nerve impulses mainly nemielinovykh fibres. As a weak foundation interacts with the receptor membrane sodium channel blocking voltage of sodium ions, the crowd of calcium receptors located on the inner surface membrane. Changes potential action in membranes of nerve cells without considerable impact on the capacity of relief. Protiwaritmicescoe effect due to the increase in the effective refrakternogo period, a decrease in excitability and automaticity Miocarda.ploho absorbed by the mucous membranes. In Injecting a well absorbed quickly hydrolyses in blood by the action esterz holinesterz and blood plasma to paraaminobensana acid and dietilaminoetanola. T_1/2 is 0.7 min, 80% of the drug is the Mochoe.pri vsasavanii or direct introduction lowers blood education acetylcholine and anxiety holinoreaguykh systems has ganglioblokirtee effect, reduces patients smooth muscles, oppressing anxiety attack and the motor cortex of the brain. And analgeziruta and protivosokova activity gipotenzive and antiaritmicski action. Alleviate down brake of retikuliarna formations barrel brain. Polisinapticalkie stupid plays. In high doses, can cause convulsions. And short anesteziruta activity (the branches anaesthesia is 0.5-1 h). In order to reduce the systemic toxicity and rollover effects used in combination with vazokonstrictorami (adrenaline). With increasing concentration of the solutions recommended dose limit. In order to prevent the development of reactions гиперчувствительност и therapy beginning with the introduction of 2 mL of 2% solution in 3 days (in the absence of side effects) - 3 ml, and then moving towards a full dose-5 ml per injection. Effective (with the / m introduction) in the elderly patients in the early stages of diseases associated with functional impairment of central nervous system (hypertension, coronary spasm receptacles and of the brain, etc.).

Indications

Local anaesthesia : infiltrazionnaya, provodnikova, epiduralnaya and spinnomozgova; Vagosimpatical paranefralnaya and blockade; Potentiation of anaesthesia funds under general anesthesia; Syndrome different genesis (also for ulcers stomach and duodenal ulcers); Fasting blood vessels, neirodermit, gemorroy, nausea.

Contraindications

Гиперчувствительност ь.

Side-Effects

Dizziness, weakness, arterial hypotension, allergic reaction (possible anaphylactic shock).

Specific guidance

Not absorbed by mucous membranes; Not surface anaesthesia. Is conjunction with the 0.1% sodium hydrochloride sports at the rate of 1 drop to 2-5 ml procaine.

Patient interaction

Do effects of anaesthesia.

Overdosing

When used in high doses may experience excessive intake accompanied by nausea, vomiting, sudden cardiovascular collapse, high nervous agitation, and tremorom convulsions, oppression Dahania.lechenie : general reanimation. In the case of intoxication after injections in the muscle hands or feet to an application form for the reduction of the drug to the general bloodstream.

Dosing and Administration

Inside, in / to the in / m, / in the way of electrophoretic rektalno. For branches anesthesia using 0.25% solutions wires 1-2% epi periduralna or 2% (20-25 ml), spinal-5% solution (1 ml). The appointment to vnutricostna Anestesia.pri paranefralna blockade imposed 50-80 ml of 0.5% solution vagosimpaticescoy - 30-100 ml 0.25% solution. To address controlling pain apply inside in / m or / 386/1989 The suicide impose slowly from 1 to 15 ml 0.25% Rastvora.vnutri using 0.25% solution to 30-50 ml 2-3 times per Deny.dl circular and paravertebralna block eczemas and neirodermite recommended / injections to 0.25% Rastvora.lechenie hypertension, atherosclerosis, acute coronary in / m 2% solution of 5 ml three times a week, a course-12 injection (in the course of the year, possibly the four courses).

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