Etomidate

Chemical name

Ethyl ether (R)-1-(1-фенилэтил)-1H-имид азол-5-карбоновой acid

Gross

C14-H16-N2-O2

Of drugs

The drugs-publeanestezirutee. The effect is linked to Gamkmimeticakimi characteristics : increased subcortical brake influences and oppression ascending retikuliarna formation by reducing the permeability of the membrane of nerve cells in those currents of sodium ions, resulting in the violation of mejsinapticescoy transfer. Decreases bleeding and the inner pressure decreases cortisol concentration in the serum. Not stupid breath, although the potential to cause short-term movements will not affect the release of gistamina fabric depot and cardiovascular system. None analgezirutaya and miorelaksirutaya activity. After the on / in a 76% binds to plasma proteins. Treated biotransformation in the liver with the formation of active metabolites. T_1/2 is 75 min. Excreted kidneys. After the on / in the anaesthesia is a 1 minute and lasts for 3-5 minutes (with a rapid exit). The effect could prolongirovtsa sedatives and repeated injections.

Indications

Induction anaesthesia, short-term operational intervention, diagnostic manipulation.

Restrictions on the use of

Children's age (up to 10 years).

Contraindications

Hypersensitivity, immunodefitsitnye condition, sepsis, organ transplantation and tissue, pregnancy, breast-feeding.

Side-Effects

Nausea, vomiting, increase or decrease AD tahi- or aetiology, automatic bogies muscles icota, allergic reactions; Redness and pain at the injection.

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Etomidate

Chemical name

Gross

Of drugs

Indications

Restrictions on the use of

Contraindications

Side-Effects

Patient interaction

Dosing and Administration

See also

All products of this group