Foran

Roman name

Forane

The composition and the form of

Concentrate (izofluran - 99.9%) for inhalation solution; Milk in 100 ml, in the box one bottle.

Pharmacokinetics

Metabolised few izoflurana. The aftercare period only 0.17% izoflurana detected in the urine as metabolites. C_max inorganic fluoride in the serum on average considerably less than 5 mmol / l and is determined for 4 h after induction, reverting to normal in the next 24 hours There has been informed of any case of damage to the kidneys using izoflurana.

Clinical pharmacology

Rapid induction and especially awakening. Although little irritating effect may limit the speed of induction. No excessive salivation and traheobronhialnaya secretia. Quickly suppressed faringeale and laringeale though. Izoflurana application, which allows you to change the level of anaesthesia. Heart rhythm is stable. Because spontaneous breath with the increased depth of anaesthesia oppressed, a thorough Monitoring.vo the induction lowered AD, which returned to normal after the Operation.ad is on a downward path and at the time of the anesthesia directly depends on the depth, but the heart rhythm is stable. During IVL normal PaCO2 minutes of the heart remain constant regardless of the depth of anaesthesia and is supported mainly by an increase in HR. In spontaneous ventilation, resulting in gipercapnii, which in turn may increase HR, minutes of the heart may exceed the original Uroveny.mozgova bloodstream does not change on the surface anesthesia, but that the in-depth. Increasing pressure spinal fluid can be prevented or reduced by hyperventilation before or during Anestesia.izmenenia in EEG and convulsions activity very rare when Izoflurana.izofluran much less sencibilisiruet miocard to the effects of adrenaline than anfluran. Limited data show that izofluranova anaesthesia people, c / to the introduction of 1:200000 epinephrine solution of up to 50 ml does not lead to the development of jeludockovh Aritmi.myshecnaya relaxation in the normal level of anesthesia may be adequate for some surgical procedures, but to enhance relaxation requires much smaller doses neiromyshechnykh релаксантов.Изофлура�� can be used for the induction and maintenance of anesthesia.

Indications

Inhalation anaesthesia.

Pregnancy and lactation

Security for pregnant women has not been established. Krovopotera for abortions using izoflurana comparable to krovopoterei for other inhaled anesthetics. Currently, there is no adequate data to determine the place in izoflurana anesthesia in obstetrics except in the kesarevom section.

Contraindications

Hypersensitivity, malignant hyperthermia in Anamneze.tak as in the use of izoflurana anaesthesia can quickly and easily change, it is recommended that you use only carefully calibrated evaporators and monitor to evaluate inhaled and vdahaemuu concentration. The hypotension and respiratory depression may be some indication of the depth of анестезии.Клинически�� Experience with izoflurana even in the long-term exposure does not give details of hepatotoxicity. However, the lack of experience of a high repetition izoflurana did not make it possible to determine the effects of exposure to the Pecheni.kak and other halogenated products izofluran carefully applied in patients with elevated vnutricerepnam pressure. In these cases, it may be necessary giperventilatia. Izofluran markedly potenziruet the nedepoliarizuth relaxantov muscle.

Side-Effects

Sometimes the aritmiah. Marked increase in the number of white blood cells, even in the absence of surgical stress. In connection with biodegradaciei agent in the serum during and after anaesthesia izofluranom there had been a slight increase in the level of inorganic florida. Unlikely that the observed low levels in the serum inorganic ftoorida (an average of 4.4 mmol / l) can cause toxic damage to the kidneys, as they are well below the threshold levels Nefrotoksicnosti.kak and in the case of other galogensoderjath anaesthetics are gipotenzia and depression. The continuous monitoring of the AD and respiratory показателей.Поддержи��ающие measures may be needed to correct hypotension and respiratory depression due to the intensification of the level of anaesthesia. Unwanted effects during awakening (drugs, nausea and vomiting) is very rare, and are comparable with the frequency of occurrence for other anaesthetics.

Patient interaction

Izofluran potenziruet all the commonly used relaxantov, however, the effect is more pronounced in the application nedepoliarizuth muscle релаксантов.Неостигм��н removes the relaxantov muscle, but does not affect the relaxation caused by the izofluranom. All muscle relaxanta compatible with izofluranom.

Storage conditions

List B. At temperatures below 30 ° C. Away from the heat, tightly shut vial.

Shelf life

5 years

The registration

012733/01-2001

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