Halothane

Chemical name

2-Бром-2-хлор-1,1,1-трифто рэтан

Gross

C2-H-Br-Cl-F3

Characteristics

Colorless, transparent, mobile, fly with a liquid smell of chloroform, and sweet pepper taste. Density - 1,865-1,870. Boiling point, 49-51 ^ C. It is soluble in water, as well anhydrous alcohol, ether, chloroform, trihloretilene, oils. The distribution of oil / water 330. Off and ignite (pair mixed with oxygen and nitrous oxide vzravobezopasna).

Of drugs

The drugs-publeanestezirutee, analgezirutee, miorelaksirutee. Oppressing CNS and is anaesthesia. Does Evoked ganglia increases tone wandering nerve lowering Oxytocics the attack sencibilisiruet miocard to kateholaminam. Lowers system AD; Expands bronchi; Slunootdelenie down; Kashleva oppressing and emetic though. Easily absorbed and rapidly passes gistogematicalkie barriers, including GEB and placental. A small portion is metabolized in the liver. Write mainly Light unchanged to a small number of memory - (incl. biotransformation products, bromides, chlorides and triftoruxusnaya acid).

Indications

General anaesthesia : induction and maintenance of narcosis when surgery (including in the face of chronic respiratory disease), including Caesarean section.

Contraindications

Hypersensitivity, acute liver failure, jaundice, malignant hyperthermia, feohromotsytoma, adults, infants, brain damage, increased vnutricerepnogo pressure; Need of the local sports during the operation; Gynaecological operation, in which the uterus relax contraindicated; I trimester of pregnancy; The three-month period after galotanovogo narcosis.

Side-Effects

Adults, aetiology, arterial gipotenzia, respiratory depression, headache, tremor wake, postnarkozny vomiting, nausea, jaundice, hepatitis (with the re-introduction), malignant gipertermiceski kriz, postnarkozny deliri.

Specific guidance

The store alothane in isparitelh. The new drug unit thoroughly to remove traces galotana and products of decomposition.

Patient interaction

Do effect antidepoliarizuth miorelaksantov, antigipertenziveh of drugs and naperstanki m-holinomimetikov. Ters tachycardia caused by trimetafanom. It increases the risk of liver damage in the face of fenitoina. Aminoglikozida, linkomicin and deepen polimiksin neuromuscular blockade (can cause patients). Ketamine increases T_1/2, metildofa, nitrous oxide, morphine and fenotiazina-force narcosis. The likelihood of malignant gipertermii increases suxamethonium, pre-xantin.

Overdosing

Symptoms : expressed aetiology, adults, gipotenzia, gipertermiceski kriz, oppression Dahania.lechenie : IVL pure oxygen.

Precautions

It should be borne in mind that the introduction of sports, etc. simpatomimetikov increases the risk of arrhythmias. There is a need to lift levodopou for 6-8 h before the narcosis. Patients chronic alcoholism for narcosis require high doses.

Dosing and Administration

Maintenance surgical stage narcosis at concentrations of 0.5-2.0%; To give anaesthesia concentration gradually increase to 4%. The required concentration in the blood-25%; Anestezirutaya minimum concentration of 15% for adults; 1.08%, 0.92%, 0.64%, respectively, for infants and children up to 10 years of age and patients over 70 years.

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