Isoflurane

Chemical name

2-Хлор-2-(дифторметокси )-1,1,1-трифторэтан

Gross

C3-H2-Cl-F5-O

Characteristics

Transparent, colorless, stable, nevosplamenauschayasa liquid containing no additives or chemical stabilizers mild acute stale air smell, breaking with its long-term standing in the light. Do not be destroyed as a result of carbon, aluminum, iron, copper, tin and bronze.

Of drugs

The drugs-publeanestezirutee. In inhalation minimum alveolarnaya sufficient to narcosis concentration is 100% oxygen 1,05-1,28 in 70% nitrous oxide 0,37-0,56. Biotransformiroetsa slightly. In postnarkoznom period only 0.17% of the doses found in the urine as metabolites. Stages induction and exit the short narcosis. Provides moderate irritant effect. Faringealny and laringealny necessarily hardened quickly. Anaesthesia is administered, as the anaesthesia easily changed. Oppressing the respiratory system. AD declines in the induction stage, but returned to surgical phase. Deepening narcosis has hypotonia. Heart rhythm and the release of little change. Reducing the impact of offset curves. Gipercapnia adds to the variation and increased heart emissions above the level of awakening. In an in-depth anaesthesia has been an increasing cerebral blood flow, which can lead to a transitory increase pressure spinal fluid.

Indications

Ingalaii anaesthesia.

Contraindications

Hypersensitivity, genetic susceptibility to malignant gipertermii.

Side-Effects

In induction phase : a cough, difficulty in breathing, laringospazm; Phase narcosis, respiratory depression, gipotenzia, disruptions; Aftercare in the period - a slight fever, nausea, vomiting, intestinal occlusion, a breach of the liver, интеллектуально-мнес��ические disorders (2-3 days after anesthesia), the deterioration in sentiment (within 6 days), leucocytosis, tranzithornoe improved glucose, creatinine, urea nitrogen, cholesterol and alkaline phosphatase, malignant syndrome gipertermii associated with giperkatabolicescimi processes skeletal muscular and the dramatic increase in oxygen consumption, reflecting muscle rigidity, palpitations, increasing respiratory movements cianosis, human rhythm, AD instability; lower partial pressure of oxygen and pH, giperkaliemia deficit basis; kidney failure.

Patient interaction

A combination with nitrous oxide 2-3 times reduces the required minimum for narcosis alveoljarnuu concentration, and reduced the severity and arterial hypotension. Potenziruet miorelaksantov effect, especially nedepoliarizutego type.

Precautions

Used to be under the control vracha-anesteziologa. As Then, the use of antiholinergicakih drugs. Side effects occurring in the phase of induction, can be reduced by the appointment gipnoticakih doses ультракороткодейству ющих barbiturates. There is a need for careful monitoring respiratory function. In patients with diseases coronary arteries normal gemodinamicakih is particularly important to prevent miocardialna Ischemia. Tranzithornoe excess pressure spinal fluid in the deep narcosis giperventilaciei adjusted. Using izofluranovogo narcosis for the abortion can be accompanied by increased krovopoteri.

Dosing and Administration

Inhalation in narkoznogo evaporator. Is ingalatia quite izoflurana% of oxygen and the mixture of oxygen and nitrous oxide, surgical narcosis level achieved in 7-10 min. You can support ingalaciei 1,0-2,5% izoflurana combined with nitrous oxide; If using pure oxygen, it may be necessary to increase the concentration of 0.5-1%.

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