Methohexital

Chemical name

1-Метил-5-(1-метил-2-пент��нил)-5-(2-пропенил)-2,4,6(1H ,3H,5H,)- pirimidintrion (in the form of mononatrieva salt)

Gross

C14-H18-N2-O3

Characteristics

The white crystalline powder, it is readily soluble in water.

Of drugs

The drugs-publeanestezirutee, sleeping. There is a short (5-7 minutes), after awakening narcosis fast. Is analgezirute properties, but the use of the pain can cause blood Vozbussion.v binds to proteins by 73%. Easily passes through gistogematicalkie barriers, including GEB-already 30 in the brain occurs in the therapeutic (snotvorna) concentration. Not deposited (almost) in the adipose tissue, which explained (along with the intense biotransformaziei) weak ability to cumulation. Metabolised in the liver by demethylation and oxidation. Report the news.

Indications

Anaesthesia : induction, in the short-term surgical, diagnostic and therapeutic procedures involving minimal bolewami feelings, as long surgery (in combination with analgetikami drugs and inhalants anaesthetics).

Contraindications

Hypersensitivity, liver failure, cardiovascular disease, porphyria, a children's age, pregnancy and breast-feeding (after metogexitala breast-feeding should be stopped for a few days).

Side-Effects

Bophlebitis, jerkiness skeletal muscles and hypotension, despnoe, patients, laringospazm, bronhospazm, rhinitis, icota, headache, drowsiness in the aftercare period, anxiety, anxiety, drowsiness, nausea, vomiting, stomachache, allergic reaction (hyperemia, itching, urticaria, anaphylaxis), the pain at the injection.

Patient interaction

Do (mutually) effect of oppressive central nervous system. Changes removals and breeding difenina, galotana, anticoagulants, glucocorticoids, ethanol solutions containing propilenglikol.

Overdosing

Symptoms : oppression and CNS disorders, convulsions, elektrolitny imbalance and hypotension, lower round, black light, stopping Serdza.lechenie : intubation and IVL, cefuroxim plazmozamenitelei introduction vazopressornah and cardiotonikov; In the development convulsing - difenin in / in, in the case of ineffectiveness, diazepam or general anaesthesia and muscle relaxants.

Precautions

Not to be confused with a sprite, and adopt one needle acidic solutions.

Dosing and Administration

B / struino in 1% solution drip 0.2% solution. For induction narcosis, the 1% solution (at the rate of 1 mle/5 c). Dose induction narcosis lead 5-7 minutes, 50-120 mg (an average of about 70 mg). The average dose for adults 1-1.5 mg / kg To maintain narcosis can be used jet INTRODUCTION 1% solution in the time-dose 40 mg (4 ml 1% solution) every 4-7 minutes. For continuous drip infusions 0.2% solution at an average rate of 3 ml / min (1 drop / s).

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