Propanidid

Chemical name

4-[2-(Диэтиламино)-2-оксо этокси]-3-метоксибензо луксусной 20.Isopropyl acid ester

Characteristics

Butter liquid light amber. Insoluble in water (for the dissolution of an ad hoc detergent).

Of drugs

The drugs-publeanestezirutee. Effect of in / in the development through 20-40 with without being brought; Deep anaesthesia lasted for 10 minutes (propanidid Rapidly hydrolyses holinesterzoy blood plasma), in addition to saving corneal and pupilary though; Recovering consciousness after 2-3 min after the end of surgery the narcosis. Is gistamina release of the code Kletok.v liver destroyed. Products biotransformation kidney removed.

Indications

Anaesthesia in case of a short-term dental and surgical patients (vpravljenie bruising, repozice otlomkov bones, joints withdrawal, O) interventions, painful instrumental diagnostic or therapeutic procedures (endoscopy, bronhografia, biopsies, etc.), anaesthesia induction (with operations requiring long-term narcosis for potenzirovania of anaesthesia other means), labor pain relief (from exile fruit).

Contraindications

Hypersensitivity, shock, Hemolytic jaundice expressed by the human liver and kidneys, circulatory insufficiency, including coronary, or heart problems, hypertension, acute alcohol intoxication, the propensity to cramps or bronhospazmu, child (up to 4 years) and old (over 60) age.

Side-Effects

Giperventilatia short movements, bronhospazm, tachycardia, hypertension, nausea, vomiting, icota, muscle apnoea, sweating; Bophlebitis, hyperemia and soreness in the course of blood in the place of the introduction.

Patient interaction

Do effect inhalation anaesthesia drugs. Deepens miorelaksaciu caused ditilinom (can cause respiratory).

Overdosing

Symptoms : agonalnaya stage narcosis, a sharp oppression and breathing sossoudodwigatelnogo points lower and the frequency of breathing, asphyxiation, heart failure, falling AD expansion Zraczkow.lechenie : eliminaie activities (with a mandatory introduction), the maintenance of vital functions.

Precautions

To prevent trombophlebitis left for the subsequent issuance vein needle should be washed with saline solution or novohammo. Be wary combine with atropinom and hypotensive means.

Dosing and Administration

In / in slowly through needle with a wide opening (with a relatively high viscosity solution). Dose determined individually, taking into account age, body mass index, severity of condition, surgery and the general condition of the patient. Adults for 5-minutny narcosis-500 mg. The average dose of 5-10 mg / kg (5% solution). The weakened patients and the elderly dose of 2-3 mg / kg (2.5% solution). Children under 4 years of age-150 mg, 4-6 years, 150-200 mg, 10 years, 200 to 300 mg, 10-16 years - 300 mg, over 16 years of age, depending on the development and the overall conditions at July 5, 1910 mg / kg body weight. The extension of the (regardless of the blink reflex) can be re-dose 2 / 3 or 3 / 4 point (not more than 1.5-2 g).

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