Propofol

Chemical name

2,6-бис-(1-Метилэтил)фен��л

Gross

C12-H18-O

Of drugs

The drugs-publeanestezirutee, sedative. After the on / in is a balance between the plasma and intensively perfuziruemami tissues (brain), by reducing the concentration in the blood (more than 50% dose goes to the well perfuziruemye fabrics). As tissue saturation velocity level sossoudistom with decreasing. The infusions resulted in a rapid awakening. Cl ranges from 1.6 to 3.4 l / min for adult weight of 70 kg. Glukuronidiruetsa in the liver with the formation of active metabolites, silent tribute. Anesthesia is often parallel with the emergence of movements, duration is typically 30-60 sec. Maintenance of anesthesia was reduced ventilation.

Indications

Induction and maintenance of anesthesia, sedation in the IVL.

Restrictions on the use of

Early age children (up to 3 years), breast-feeding (should stop breastfeeding).

Contraindications

Гиперчувствительност ь.

Side-Effects

Short stops breathing, shortness of breath; Rarely convulsions, opistotonus, swelling light; During awakening, headache, nausea, vomiting, postoperative fever (rare).

Specific guidance

Risk of pain in the course of drugs can be reduced dramatically in the infusions through the veins of large diameter, or when the solution of lidocaine. Injection may make only specially trained personnel in the immediate application of IVL, oksighenoterapii, mobile activities.

Patient interaction

Compatible with drugs for spinal and epiduralna anaesthesia, the drugs used in the Then, in miorelaxanthami and analgetikami.

Overdosing

There oppression of the heart and respiration rate. Treatment of symptomatic against IVL (oxygen), the maintenance of hemodynamics (introduction liquids and vazopressorov).

Precautions

In cases where there was a risk of side effects associated with activation wandering nerve, it is appropriate to the introduction of anaesthetic / in a holinolitika. It should not be used in obstetric practice, it propofol crosses the placental barrier and can cause mental depression (possibly use in the first trimester, in the course of abortion).

Dosing and Administration

B / 386/1989 The introductory lecture adults being 40 mg every 10 (before clinical signs of pain), for children over the age of 8 years old-2.5 mg / kg To maintain narcosis using either constant infuziu or re bolusnye introduction. Dose picked individually adequate anaesthesia is achieved with the introduction of Quick 4-12 mg / kg / h, children 9-15 mg / kg / h. The sedative effect in intensive care for patients in IVL, in / in infuziruut Quick 0,3-4 mg / kg / h.

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