Rekofol

Roman name

Recofol

Characteristics

While jirorastvorimy, quick preparation for neingaltini general anesthesia.

Pharmacokinetics

After the on / in the relatively quickly is a balance between plasma and intensively perfuziruemami tissues (brain), as more than 50% of the substance goes into tissue. As they saturation decreases speed down the propofola in sossoudistom course. It overcomes gistogematicalkie barriers, including placental, GEB. Cl ranges from 1.6 to 3.4 l / min for adult body weight of 70 kg. During the time of the anesthesia does not accumulate in the body in a clinically significant quantities. Metabolised mainly in the liver with the formation of inactive kongugatov (glukuronida and sulphates). Return with urine.

Farmakodinamika

Provides short-term action and a rapid onset of pharmacological sleep for a 30-60 with without incident action involuntary muscle cuts at the stage of the anaesthesia. The drug can be described trejcasteva open model : rapid distribution of the blood and tissues (T_1/2 - 2-3 min), the rapid loss of blood during metabolism (T_1/2- 30-60 min) and a slow final phase, during which propofol inferred from the weak perfuziruemah tissue. The restoration of consciousness is quickly (with the end of infusions). It oppresses the secretion of hormones napochechnikov crust, and had little effect so far on the release of gistamina. Found also that Rekofol relieves itching caused by opiates and liver diseases.

Indications

Induction narcosis, and the maintenance of general anesthesia, the sedative effect in intensive care, including IVL, surgical or diagnostic procedures combined with regionarna or local anesthesia.

Pregnancy and lactation

Contraindicated during pregnancy (permeates through GEB and has a dampening effect on the foetus, contraindications for anaesthesia in pregnancy). At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, the children's age : up to three years for nurses, and 16 years for the sedative effect pregnancy.

Specific guidance

The introduction. To reduce the pain induction dose immediately before use can be mixed with plastic sprite with lidohammo (10 mg / ml) for injection in the ratio : 1 hour lidocaine 20 hours propofola. Divorced solutions to be used for the runways приготовления.Поскол��ку Rekofol ® does not contain preservatives to prevent the growth of harmful bacteria and other micro-organisms, breeding, as well as the introduction of the drug should be in aseptic conditions. Any liquid solutions to be applied in conjunction with Rekofolom ®, should be as close as possible to the location kanuli. The drug should not be imposed through microbiological Filtr.v line with the general recommendations on the use of lipid emulsions of Infusion nerazvedennogo propofola should not exceed 12 hours at a time.

Patient interaction

Compatible with drugs for spinal and epiduralna anaesthesia, PP used in the Then, and miorelaxanthami analgetikami. If you are applying to funds urejatmi variation increases the risk of bradikardii expressed. Farmatsevticeski incompatible with the infusion solutions other LAN compatible with the 5% solution dekstrozy, lidohammo.

Precautions

The drug can only специалистами-анесте��иологами. During a drug patients need to be constantly reviewed in order to identify early signs of possible hypotension, obstructive respiratory tract gipoventilation and underdevelopment saturation of blood oxygen. To use caution when accompanying gipovolemii, epilepsy, violations of lipid (including pathological giperlipedemia), Cardiovascular diseases, respiratory, liver and kidney failure in elderly patients. Special precautions should be made for patients with high vnutricerepnam pressure and low middle AD, as there a3ce is a risk of a significant reduction in vnutricerepnogo perfuzing pressure. In cases where there was a risk of side effects associated with activation wandering nerve, it is appropriate to the introduction of anaesthetic / in a холинолитика.Учитыва�� that the product is a lipidnuu emulsion, in the imposition patients with human lipid metabolism, including Pathological hyperlipidaemia, need special care. The long introduction to the content of lipids in the blood and, as appropriate, reduce dose of preparation. Be wary of during the drivers of vehicles and people skills relate to the high concentration (should refrain from the operations within 24 hours after the cessation of anaesthesia). To ensure adequate analgesia should be used analgeticalkie funds (own analgeticski effect propofol no). We must await the awakening of the patient after general anesthesia before disconnecting it from the apparatus. It should be noted that the effects of general anesthesia could affect the ability of the patient to perceive post instructions.

Storage conditions

List B. The temperature 2-25 ° C (not freezing)

Shelf life

3 years

The registration

010769

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