Amisulpride

Chemical name

4-Амино-N-[(1-этил-2-пирро лидинил)метил]-5-(этилс ульфонил)-2-метоксибен замид

Gross

C17-H27-N3-O4-S

Of drugs

Drugs, the neuroleptic, antipsihoticescoe, sedative. Selectively blocking D_2- and D_3-dofaminergicakie CNS receptors. Ters productive pronounced symptoms and block.

Indications

Schizophrenia : productive state (paranoid schizophrenia, acute psychosis with deliriem), and secondary negative symptoms, the primary adverse condition (residues of psychosis, block leavers), the chronic state of distress (distimia).

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, feohromotsytoma, prolaktinzawisimae tumors (including pituitary prolactinoma), breast cancer, pregnancy, breast-feeding, child and adolescence (15 years).

Side-Effects

Depression, drowsiness, early or late psoriasis, ekstrapiramidnye disorders ortostatical gipotenzia, impotence, frigidity, giperprolaktinemia (including pain in the milk glands, amenorea, galactorea, ginekomastia, sexual dysfunction), the increase in body mass index, neirolepticeski malignant syndrome, insomnia, anxiety, agitation aetiology, epileptic seizures, increased PQ interval on the ECG.

Patient interaction

Is antagonist levodopa. Do effects gipotenziveh and deprimiruth (analgesics, anesthetics, antiallergic, alcohol, etc.) products.

Precautions

With the utmost care designate of renal failure, epilepsy, parkinsonizme patients older; While the drivers of vehicles and people skills relate to the high concentration of attention. All treatment precluded admission of alcohol.

Dosing and Administration

Inside, in / m. In productive conditions (including acute episode psihoticeski) 800 mg / day in divided doses (maximum daily dose of 1200 mg), and primary and secondary negative syndromes, 50-300 mg / day (can be one).

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