Chlorpromazine

Chemical name

2-Хлор-N,N-диметил-10Н-фе��отиазин-10-пропанамин (and as hydrochloride)

Gross

C17-H19-Cl-N2-S

Characteristics

White or white with weak Navy melkochristalliceski white powder. Slightly gigroskopichen, dark to light. Very easily soluble in water. Powder and aqueous solutions of the darker light.

Of drugs

Drugs, the neuroleptic, antipsihoticescoe, sedative, miorelaksirutee, protivorvotnoe. Does central adrenergicakie and dofaminergicakie receptors. The alleged ill-drawn, a large portion is biotransformation in the liver. Report the news and the intestine (for days). One of the main features of hlorpromazina (to be compared with others. Neiroleptikami) is a strong sedative effect. Overall comfort with the combined oppression uslovnoreflectorna activities and, above all, двигательно-оборонит��льных reflexes, reduced spontaneous motor activity rasslableniem skeletal muscles, decreased reactivity. Consciousness is (use large doses of hypnotic effect). Oppressing different interotseptivee though, has expressed protivorvotnam and protivojikotnam effects antigistaminna, m-holinoliticaskoy and prolaktinogenna activity. Provides gipotermicescoe effects (especially in the artificial hypothermia), but in some cases with the introduction Injecting the body temperature can rise. Moderately less pronounced inflammatory reaction, reduces blood pressure lowering activity kininov and gialuronidasy has antigistaminnoe li 15295 ttle effect. Decreases Sad and Dad was tachycardia. He expressed kataleptogenne properties. The main feature is the combination of antipsihoticski action with the ability to influence the emotional sphere. Eliminates various psychomotor stimulation crazy and hallucinations, fear and anxiety in patients with schizophrenia and neurosis. The development extrapiramidale violations. Duration of therapeutic action in a one-time is about six hours

Indications

In psychiatry, acute and chronic paranoid and / or galloucintorne state agitation in schizophrenia (galloucintorno-bredovy, gebefreniceski, katatoniceski syndromes), maniacal bring in маниакально-депресси��ном psychosis, psychotic disorders and epilepsy, depression ajitirovannaya (with and presenilnom �аниакально-депрессив ном psychosis), alcohol psychosis, as well as other diseases with symptoms productive and criminal. In Neurology, the muscle strength, torpidnyi pain syndrome, persistent insomnia, nervous status (with the poor preparations etc.). As protivorvotny means, Ménière disease, uncontrollable vomiting pregnant, in the treatment of protivoopujolevami drugs, radiation therapy. In anesthesiology for Then and potenzirovania narcosis, and artificial hypothermia (composed of the so-called Etudes mixtures). In dermatology, zudaschie Medicine.

Restrictions on the use of

Jelchnokamennaya and pochernkamennaya disease pielit severe, active rheumatoid arthritis, a disease hospital stomach or duodenal ulcer (function inside).

Contraindications

Severe hepatic or renal failure, progressive systemic disease brain and spinal cord, komatosnye state, the brain injury expressed oppression blood, miksedema, urological heart disease, active rheumatoid arthritis, tromboamboliceski syndrome, a disease bronhoektatical (late stage), and jelchnokamennaya anesthetic disease, acute pielit, increased erosivno-yazvennah tract diseases, pregnancy.

Side-Effects

Local : by ingestion solution on the skin and mucous irritation, tissue; In the m-a infiltrata with on / in the introduction-flebit. General : with long-term use-neirolepticeski syndrome (parkinsonism, akatizia, indifference slow reactions), depression; In the on / in the introduction-gipotenzia; The ingestion - dyspeptic symptoms (nausea, vomiting, constipation). Rarely, jaundice, agranulozitos, skin pigmentation, aphykia flat; Allergic reaction (rash, swelling, photosensitization).

Patient interaction

Antatsida and zimetidin reduce suction. Do effect pills, drugs, analgesics and local anaesthetics protivosudorozhnykh funds, reduces cardiac glycosides. When combined with a m-holinoblokatorami summation holinoliticakih effects. Estrogens increase neirolepticalkie properties.

Overdosing

There neirolepticski syndrome resistant gipotenziei, gipotermiei, furious, later toxic hepatitis.

Precautions

In long-term care, there is a need to control the cell blood protrombinovy index, the liver and kidneys. After injecting patients preferably within 1-1.5 hours in a horizontal position.

Dosing and Administration

Adults, inside-the 25-600 mg / day, the maximum single dose of 300 mg. V / m to 1 g / day, the maximum single dose of 150 mg. In / in-up to 250 mg / day, maximum single dose of 100 mg. For children into 1 mg / kg body weight per day.

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