Chlorprothixene

Chemical name

(Z)-3-(2-Хлор-9Н-тиоксанте н-9-илиден)-N,N-диметил-1- пропанамин (and as hydrochloride)

Gross

C18-H18-Cl-N-S

Characteristics

Yellow crystalline powder with weak smell.

Of drugs

Drugs, the neuroleptic, antipsihoticescoe, antidepressant, protivorvotnoe, protivosudorozhnoe. And antiserotoninova, holino- and adrainoliticescoy activity. Dofaminove blocking receptors in polineironalnah neurotransmission in the brain (dosage productive symptoms of psychosis, delirium and hallucinations), as well as in nigrostriarna zone and тубулоинфундибулярно й (as a matter of ekstrapiramidnye disorder). Links gistaminove, serotoninove, alfa-adraino- holinoretseptora and in the central nervous system, oppressing trigger zone vomitoxin Centra.pri ingestion rapidly absorbed. Step is a 20 min. Treated presistemnomu metabolizmu (in the walls of the bowel and liver); The effect of a "plasma concentration is always lower than those in the / m introduction. Penetrates through the placental barrier and in breast milk. Report kidney and intestinal primarily in the form of metabolites (with a daily dose of 300 mg, about 29% of hlorprotiksena, 41% hlorprotiksena sulfoxida). T_1/2 is 8-12 hours

Indications

Psychotic, incl. schizophrenia, depressive moods during menopause, frequent institute associated with the fear and stress, discirkulatornaya encephalopathy, a fractured skull deliri drink, sleep disturbance and anxiety, psychosomatic, nervous disorders in children, premedikation, posleoperazionny period scorch Medicine with hard going.

Contraindications

Hypersensitivity, poisoning means oppressive central nervous system (including alcohol), ortostaticeski collapsed feohromotsytoma, epilepsy, parkinsonism, the propensity to kollapsam expressed by the human kidney, liver, heart and respiratory diseases, glaucoma zakratougolnaya, male gravis, pregnancy, breast-feeding (should abandon breastfeeding), the old and children (up to 6 years old) age.

Side-Effects

206 braking ekstrapiramidnye disorders, increased fatigue, headache, dry mouth, a breach of ccomodation and view ortostatical gipotenzia, tachycardia, constipation, urine disorder, jaundice, amenorea, galactorea, ginekomastia, reduced libido, changes Carbohydrate exchange, increased appetite, increased body mass index, agranulozitos, lakopenia, photosensitization, fotodermatit, syndrome "lifting."

Patient interaction

Do effects of general anesthetics, narcotic analgesics, sedatives and tranquilizers means more doses, ethanol and etanolsoderjath drugs.

Precautions

Termination treatment recommended gradually reducing the dosage. During the therapy should be avoided receiving alcohol, exposed to extreme temperatures, solar potentially hazardous activities that require increased attention and psychomotor speed reactions.

Dosing and Administration

Inside : adult-to 400 mg per day. Most of the doses are usually appointed overnight.

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