Clozapine

Chemical name

8-Хлор-11-(4-метил-1-пипер азинил)-5Н-дибензо[b,e][1, 4]диазепин

Gross

C18-H19-Cl-N4

Characteristics

Melkochristalliceski sulphur powder. Virtually nerastvorim water, it is difficult soluble in alcohol.

Of drugs

Drugs, the neuroleptic, antipsihoticescoe, sedative, miorelaksirutee. Does dofaminove CNS receptors and prevents dofaminova transfer bazalnah gangliah and in the limbic front of the brain. Along with antidofaminovmi, the central and perifericescimi holinoblokirutmi, perifericescimi альфа-адренолитическ��ми properties. Effectively eliminates nervous, and behavioral disorders mnesticskie weakens acute emotional experience, aggressiveness and impoulsivnosti behaviour. No impact on the higher intellectual functions, little is extrapiramidale disorders. Quickly and sufficiently absorbed after administration inwards. Return to jelchew, urine and faeces.

Indications

Acute and chronic forms of schizophrenia, maniakale state маниакально-депресси��ный psychosis, various psychotic state agitation in psihozah, aggression, sleep disorders.

Restrictions on the use of

Cases of liver, kidneys and the cardiovascular system, the increased propensity to cramps, epilepsy, glaucoma закрытоугольная, Denmark prostate, atony bowel disease интеркуррентные with febrile syndrome.

Contraindications

Diseases of the blood, alcohol and toxic psychosis, male, pregnancy, breast-feeding (no breastfeeding).

Side-Effects

Muscular weakness, drowsiness, sputannosti consciousness, dry mouth, sometimes gipersalivacia, paresis ccomodation, tachycardia, a decline AD and dizziness (ortostatical hypotension), known zubza T at the ECG, hyperthermia central genesis, the worsening of chronic or latent infection pockets (tonzillit, periostit, piodermia) granulozitopenia (up to agranulozitoza).

Patient interaction

Do sedative effect, narcotic, and analgeziruth sleeping-, alcohol, the influence of central nervous system drugs antigistaminnah weakens - levodopa (and dofaminomimetikov etc.). Suction of the bowel worsening in the employment gel-strukturnah antatsidov and holestiramina.

Precautions

The treatment should not be driving or perform work that requires increased attention and rapid mental and motor reaction; A periodic (weekly initially, and then every three to four months) to monitor the blood picture, with the emergence of granoulozitopenia treatment immediately cease.

Dosing and Administration

Inside (granules of a single throw in 5-10 ml of water) after eating on the 50-200 mg 2-3 times a day, daily intake for adults : home-150-300 mg, the average 400-mg, the highest-600 mg. For maintenance therapy and outpatient appoint 25-200 mg. Under dose for children 6-8 years, 10 mg, 8-15 years, 10-20 mg daily dose for children 6-8 years, 30 mg, 8-15 years, 30-60 mg, it is divided into two reception; Highest daily intake for children to 100 mg.

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