Droperidol

Chemical name

1-[1-[4-(4-Фторфенил)-4-окс��бутил]-1,2,3,6-тетрагидр��-4-пиридинил]- 1,3-дигидро-2Н-бензимид��зол-2-он

Gross

C22-H22-F-N3-O2

Characteristics

Svetlo-kremovi crystalline powder. Storage in air and light yellow. Virtually nerastvorim water, little soluble in alcohol.

Of drugs

Drugs, the neuroleptic, antipsihoticescoe, sedative, protivorvotnoe, protivosokowoe. Does dofaminove receptors (mainly D_2) in the subcortical areas of the brain (black substance, polostoe body bugornaya, mejlimbical and mezokorticalnaya area), the central oppresses альфа-адренергически�� structure violates return neironalny capture and deposit Norarenalina.pri in / in and / m C_max a plasma achieved in 15 minutes. The plasma protein binds 85-90%. T_1/2 averages 134 min. Provided in the form of metabolites and unchanged to (1%), through the kidneys and intestine (11%). Increase peripheral vessels by reducing the CSO and AD. Decreases pressure in the pulmonary artery, reduces pressornoe aritmogennoe and the adrenaline. Has strong kataleptogenna activity. After injecting the place in 10 minutes and reaches a peak after 30 min. Sedative effect continues 2-4 pm The combined use of the fentanyl is fast and neirolepticeski analgeziruty effect, muscle relaxation, warns shock to protivorvotnoe effect. When you use in the face of conductive anesthesia (spinalnaya, periduralnaya) to the blockade intercostals nerves and the sympathetic nervous system, which makes it difficult to breath, enhances peripheral vessels and hypotension. Patients receiving gipotenzivee funds, a few days before the droperidola be gradual reduction of the dose of drugs, and then lifting them completely. Patients who are feohromotsytoma after droperidola may experience severe hypertension and tachycardia.

Indications

Neiroleptanalgesia (usually in combination with fentanyl), in preparation for the research tools, including endoskopiceski and surgical procedures narkozu; pain and shock in trauma, cardiac infarct, heavy strokes, oteke lungs, hypertonic kriz, agitation, hallucinations, nausea and vomiting during diagnostic and surgical manipulation.

Restrictions on the use of

During pregnancy is used in cases where the presumed benefit to the mother outweighs the potential risk to the fetus.

Contraindications

Hypersensitivity, ekstrapiramidnye violations Caesarean section, a young child (up to 2 years).

Side-Effects

Hormone, drowsiness, hallucinations, depression, arterial gipotenzia, ekstrapiramidnaya symptoms in high doses, the concern anxiety, the fear. Rarely, dizziness, chemical, laringospazm, bronhospazm, anaphylacticskie reaction. When combined with the introduction of fentanyl possible development of hypertension.

Specific guidance

Applied only in a hospital environment.

Patient interaction

Derivative benzodiazepine reinforcing, and agonists dofamine receptors (bromokriptin) weaken the effect. Increases activity of opioid analgesics, tranquilizers and anaesthesia funds.

Overdosing

Many increasing extent side effects against the backdrop of arterial Gipotenzii.lechenie : in the case of violations extrapiramidale apply противопаркинсоничес кие tools; AD decline kupeeroout analeptikami and simpatomimeticakimi means; gipovolemii to show for BCC.

Precautions

To prevent Orthostatic Hypotension should be careful when transporting a patient (it is not possible to alter the position of a body). Older and physically impaired patients to reduce the initial dose. The caution used in the human liver and kidneys.

Dosing and Administration

In / in, in / m. For Then adult-2.5-5 mg (1 ml) in / m for the 15-45 minutes before surgery; Children-100 µ g / kg body weight. For induction narcosis adult-in / 15 to 20 mg (6-8 ml), the children in / in the 400 µ g / kg body weight or / m 300-600 µ g / kg body weight. The aftercare period adults appoint 2.5-5 mg (1 ml) in / m at 6900 interval.

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