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Eglonil

See also Sulpiride

Roman name

Eglonil

The composition and the form of

Capsule-1 kaps.sulpirid-50 megawatts blistere 10 pcs. ; In a box 3 Blister.tabletki-1 tabl.sulpirid-200 megawatts blistere 12 pcs. ; In a Box 1 Blister.rastvor for intramuscular injection-1 amp.sulpirid-100 megawatts blistere 6 vials; in a Box 1 Blister.rastvor reception inside (preferably for children) 0.5% mlsulpirid 100-500 mg (1 c.lojka 5 ml, 25 mg and 20 drops to 5 mg) in glass bottles of 200 ml.

Pharmacokinetics

After injecting 100 mg C_max (2.2 mg / l) is determined after 30 minutes, after administered orally 200 mg (0.73 mg / l), through 4.5 hours Bioavailability after intake of the 25-35% (may vary in individual patients). Easily pervades all bodies, particularly rapidly in the liver and kidneys, slower in the brain tissue (the number concentrated in gipofize). Linking plasma protein-40%. T_1/2 about 0730 There is biotransformation. The Cl-126 ml / min. Breeding occurs mostly kidneys (92% imposed dose) by clubockova filtering and glands; A small portion (about 1% of daily intake) excreted in breast milk.

Farmakodinamika

In small doses, acting at the level of central dofaminergicakih receptors has rastormaerveschee effect. At doses greater than 600 mg / day reducyruet productive symptoms (antipsihoticeski proper effect).

Indications

Acute and chronic psychosis (block, crazy, sputannosti consciousness agrammatizm, abulia) schizophrenia; Neurotic condition, accompanied by block; Psihosomatical symptoms (especially with ulcers stomach and duodenal ulcers and gemorragicescom rectokolite).

Pregnancy and lactation

With long-term use of high doses (more than 200 mg / day) in neonatal sometimes been ekstrapiramidnyi syndrome. Therefore, the need for treatment for pregnant and lactating women to reduce dose and reduce the duration of treatment.

Contraindications

Hypersensitivity, on suspicion feohromotsytomu.

Side-Effects

With long-term use at high doses can sometimes block, drowsiness, giperprolaktinemia, amenorea, galactorea, ginekomastia, impotence, frigidity, the increase in body mass index, early (spastical, wryneck oculomotor violations patients chewing muscles), and later psoriasis, ekstrapiramidnye disorders ortostatical gipotenzia, neirolepticeski malignant syndrome (hyperthermia).

Patient interaction

Ters effect of levodopa increases pronounced downward AD against the backdrop gipotenziveh funds; Incompatible with alcohol and other drugs, oppressive central nervous system (linking sedative properties).

Precautions

Be wary appoint patients with renal failure, epilepsy, parkinsonizmom, the elderly and the newborn; While the drivers of vehicles and people skills relate to the high concentration of attention.

Storage conditions

List B. The temperature is not above 30 ° C

Shelf life

3 years

The registration

012589/03

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