Escazin

Roman name

Escasine

The composition and the form of

1 ml for intramuscular injection contains trifluoperazina (as hydrochloride) 1 mg; Injection in 5 ml, in a box 10 pcs.

Of drugs

Antipsihoticescoe, neuroleptic, anxiolytic, protivorvotnoe. Does postsinapticalkie dofaminove, alfa-adrenergicakie, serotoninove, N_1-gistaminove m-holinoretseptora and in the central nervous system.

Farmakodinamika

Psychotropic effect is a combination effect neirolepticski mild stimulant. In high doses has expressed antipsihoticescoe Effects (dosage галлюцинаторно-бредо��ой status). And sedative (it increases with increasing dose) and gipotenzive effect.

Indications

Psychotic disorder with галлюцинаторно-бредо��ой symptoms, including schizophrenia (especially paranoid), inwaluzionny psychosis, psychotic disorders and organic diseases and toxic lesions (also for alcoholism), central nervous system, schizophrenia disorder; nepsihoticalkie anxiety disorders; impoulsivne behavior (for people with lower neprogressirutm intelligence); vomiting central genesis (treatment and prevention).

Pregnancy and lactation

When pregnancy is possible if the expected effect of therapy outweighs the potential risk to the fetus and the child.

Contraindications

Hypersensitivity expressed by the human liver, mielodeprescia, coma, simultaneous preparations oppressive central nervous system (barbiturates, opiates, etc.).

Side-Effects

From the nervous system and sensory organs : dizziness, violation of consciousness, weakness, drowsiness, anxiety, insomnia, lack of view; To the reception of high doses ekstrapiramidnye violation (distonia, tremor, akatizia); Diskinesia later; It is rarely malignant neirolepticeski Sindrom.so the circulatory system and blood (blood, gemostaz) : moderate ortostatical гипотензия.Аллергиче��кие reactions : Fotosencibilizace.prochie : muscle weakness, swelling, anorexia, dry mouth, increased body mass index.

Patient interaction

Do effect preparations oppressive central nervous system, including alcohol (possibly respiratory depression). In combination with tricyclic antidepressants, maprotilinom, MAO inhibitors increases the risk of developing malignant syndrome neirolepticski with protivosudorojnami means, possibly lowering convulsant threshold the drugs for the treatment of hyperthyroidism, increasing the likelihood agranulozitoza, with the means that are ekstrapiramidnye reaction, an increase in the frequency and severity extrapiramidale violations with hypotensive drugs increases the risk of Orthostatic Hypotension in prohlorperazinom-possible prolonged loss of consciousness. Ters effect of oral anticoagulants, sosudossoujiwati effect of ephedrine, gipotenzivny guanetidina effect. Propranolol increases (mutually) concentration in plasma.

Precautions

Caution must be exercised in the appointment of patients with cardiovascular diseases, including with aritmiami, zakratougolna glaucoma, myasthenia, sound giperplaziei prostate cancer and living in regions with extreme temperatures (perhaps the moisture). It should not be used in conjunction with the drivers of vehicles and people skills relate to the high concentration of attention.

Dosing and Administration

V / m, the initial dose of 1-2 mg every 4 to 6 hours Older people starting dose should be reduced to $ 1.3 billion. Children (if necessary) - initial daily intake at the rate of 1 mg / kg in a number of techniques.

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