Flupentixol

Chemical name

4-[3-[2-(Трифторметил)-9H-т иоксантен-9-илиден]про пил]-1-пиперазинэтанол (and as dihydrochloride or dekanoata)

Gross

C23-H25-F3-N2-O-S

Of drugs

The drugs-antipsihoticescoe. Does postsinapticalkie dofaminove receptors in the brain. Effectively eliminates the symptoms of psychosis, including delirium, hallucinations, human thinking. Is rastormazivate (antiautisticskie) properties weakened secondary mood disorders contributes to the revitalization of patients with depressive symptoms and the lack of initiative. Enhances communication and improves social Adaptatia.posle intake of a well-drawn, but the first passage "through the liver bioavailability is only about 40%, and the concentration of plasma are lower than those in the / m introduction. C_max achieved through 3-6 hours Biotransformiroetsa (sulfookislenie, N-dealkilirovanie and glukuronirovanie) with the formation of active metabolites. Flupentixol and cis - (Z) -flupentixol decanoate penetrate the placental barrier and in breast milk. After the / m of flupentixol decanoate fermentativomu is split on the active component of cis - (Z) and -flupentixol dekanovu acid from C_max achievement by the end of the first week. T_1/2 is about 35 hours, and for flupentixola dekanoata-3 weeks. Place in the form of metabolites mainly through the intestine and part of his kidney.

Indications

Large doses (3 mg or more) : psychotic state with a predominance of hallucinations, paranoid nonsense, of thinking, accompanied by apathy, anergiei, autism; Small dose (3 mg) : depression with anxiety, asthenia, lack of initiative; Chronic nervous disorders with anxiety, depression, apathy, psychosomatic disturbances asthenia manifestations, acute and situatin of an 5a8 xiety disorders and the emotional strain.

Contraindications

Comatose state, causing hyperactivity, acute alcohol poisoning, barbituratami, analgetikami drugs, pregnancy, breast-feeding (for the period of treatment needed to stop breast-feeding).

Side-Effects

Ekstrapiramidnye disorders later diskinesia, insomnia or drowsiness, neirolepticeski malignant syndrome (hyperthermia, muscle rigidity, human consciousness, in conjunction with unstable AD palpitations and heavy sweating), changes liver samples.

Specific guidance

Solution for injection depot should not be confused with other solutions for injection (except klopicksola-akufaz of ko-ingyektion).

Patient interaction

Do (in high doses) effects of alcohol, barbiturates and other funds oppressive central nervous system, reduces levodopa, etc. adrenergicakih substances. Ters gipotenzivne influence guanetidina and its analogues. The risk of disorders extrapiramidale increase metoclopramide and piperazine.

Overdosing

Symptoms : drowsiness, coma, ekstrapiramidnye disorders, convulsions, arterial gipotenzia, shock, or hypothetical Gipertermia.lechenie : washing stomach and reception sorbent (if flupentixol appointed interior). Convulsions kupeeroout diazepam and ekstrapiramidnye symptoms biperidenom, for the normalization of AD should not be used adrenaline (possibly up his demotion).

Precautions

With long-term therapy, especially high doses, a careful monitoring of patients. Be wary when appoint sudorozhnom syndrome, chronic Hepatitis, cardiovascular diseases, persons by car or other potentially dangerous machinery.

Dosing and Administration

Inside, in / m. Doses for the treatment of psychosis (3 mg or more) components individually, depending on the condition of the patient. Initial daily intake, 5-15 mg 2-3 admission (up to 40 mg / day); Supportive therapy, which is 5-20 mg / day, on the morning news. To treat border states (doses up to 3 mg) for the 1 mg once a day or 0.5 mg twice a day every day; After one hour dose can be increased to 2 mg / day; If the effect of the maximum dose (3 mg / day) was not available for the one week exhibition cancelled. Solution for injection depot on a dose of 200 mg (0.5-2.0 mL) every 2-4 weeks. After heavily acute symptoms gradually reduce the dose to the supporting-200 mg every 2-4 weeks.

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