Fluphenazine

Chemical name

4-[3-[2-(Трифторметил)-10H-��енотиазин-10-ил]пропил ]-1-пиперазинилэтанол (and in the form of kaproata, dekanoata or dihydrochloride)

Gross

C22-H26-F3-N3-O-S

Characteristics

The white crystalline powder, almost odourless. Rat in the water, a moderate in alcohol and ether, very low in chloroform and acetone.

Of drugs

Drugs, the neuroleptic, antipsihoticescoe, protivorvotnoe. Has expressed blocking influence on dofaminove D_2-retseptora CNS, coupled with moderate braking adrenergicakih structures. Impact aguirutee influence on the crust brain retikuliarna formations. Heavy and long antipsihoticeski effect develops in the face of aguirutego (energezirutego). Antagonist was moderate and there is at higher doses. Takes action and aggression caused symptoms productive. Unlike other derivatives fenotiazina characterized more by actions (on neurotic activity 25 times stronger aminazina), and less pronounced ekstrapiramidnami and somatic disorders. In low doses stimulates motoriku. Especially effective for the nuclear zlokacestvenno (gebefrenicescoy, katatonicescoy, early paranoid form), and ongoing long-term Shizofrenia.pri ingestion quickly and adequately absorbed. Passes through gistogematicalkie barriers, including GEB and placental. Return with urine and partly jelchew. As a dekanoata (solution in the oil) is the long-term because fluphenazine released gradually. After one in the / m injection flufenazina dekanoata effect until 1-2 weeks or more (depending on dose).

Indications

Schizophrenia (all forms), acute and chronic psychosis (including paranoid), the underlying causes of fear and psychomotor stimulation psychosis shizofreniceski type, especially with a picture of apathy and indifference, senile psychosis, vomiting caused by chemotherapy anticancer, trochaic Gentington, syndrome Gilles de la Turetta, gipersexuale violations.

Contraindications

Гиперчувствительност ь (incl. to fenotiazinam etc.), organic diseases and injuries brain (especially hypothalamus), acute depressive condition, epilepsy, feohromotsytoma, kidney, liver and heart failure, coma, Denmark prostate cancer, diseases of the blood, lakopenia, pregnancy, breast-feeding (at the time of treatment cease breastfeeding), children aged up to 12 years old (flufenazina decanoate).

Side-Effects

Fall, block, disorientation, depression, violations of intellectual functions, coordination of movements, the decline AD, the conductance and heart rhythm, ECG changes, myalgia, stomatitis, nausea, vomiting, constipation, jaundice holetsatical, hyperpigmentation skin, dermatitis, increased body mass index, galactorea, amenorea, ginekomastia men agranulozitos, photosensitization, allergic skin reaction; For flufenazina dekanoata (in addition), ekstrapiramidnye disorders, Later psoriasis, giperkineza look.

Patient interaction

Do effect pills, alcohol, etc. deprimiruth funds.

Precautions

Be wary when using liver diseases and aritmiah, insufficient mitral valve tireotoxicose, Parkinson's disease, zakratougolna glaucome, coupled with gipertenzivei drugs in elderly patients, as well as working in the elevated temperatures of contact with containing insecticide. Long therapy must be accompanied by the control cells, the functional liver samples. During treatment should not engage in activities requiring increased attention rapid mental and motor reactions.

Dosing and Administration

Inside, in / m (deep in the muscle). Dose inside out, depending on the patient and his sensitivity to the drug. Treatment start with small doses, gradually increasing them to achieve an optimal effect. Adults - 1-5 mg / day, if necessary (in the hospital), 10 mg / sut. Daily dose taken 3-4 reception. Older patients appoint half dose. The conditions concern tension and fear in one dose of 1-3 mg. Children (only in exceptional cases), 0.25 mg / sut. V / m for 12,5-25 mg every 2-4 weeks. Perhaps the dose to 50 mg. The selection of individual doses.

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