Haloperidol

Chemical name

4-[4-(4-Хлорфенил)-4-гидро кси-1-пиперидинил]-1-(4-ф торфенил)-1-бутанон (and in the form of dekanoata or lactate)

Gross

C21-H23-Cl-F-N-O2

Characteristics

Amorphous or mikrochristalliceski powder from white to light yellow color. Virtually nerastvorim water limited soluble in alcohol, metilenhloride, live. Rich solution is the response of the neutral to mildly.

Of drugs

Drugs, the neuroleptic, antipsihoticescoe, sedative, protivorvotnoe. Does postsinapticalkie dofaminergicakie receptors located in mezolimbicescoy system (antipsihoticescoe effect), Hypothalamus (gipotermiceski effect galactorea), the action vomitoxin point ekstrapiramidna system; Oppressing central альфа-адренергически�� receptors. It stops the release of mediators, reducing permeability membrane presinapticakih violates return neironalny seizure and депонирование.Устран��ет Persistent personality change, delirium, hallucinations, delusions, increased interest in the environment. Affects vegetative functions (lower tone of hollow organs motoriku and secretion of digestive eliminates cramps receptacles), a host of diseases involving either, concern, fear of death. The long reception accompanied by changes in the endocrine status at the front share increased pituitary hormone products, and reduced-gonadotroponah Gormonov.pri ingestion absorbed about 70%. In the blood by 92% associated with plasma proteins. Intensive distributed fabric, as easily passes gistogematicalkie barriers, including GEB. Metabolised in the liver are liver recycling. When administered orally concentration in the plasma than in the / m introduction, the first passage "through the liver and also can vary widely. Settings relationship between concentration in the plasma and the effect has been established. T_1/2 is 13-40 hrs, Return with urine, and jelchew faeces, enters the breast milk. After the / m of extended drug form (galoperidola dekanoata) is the slow and continuous absorption galoperidola through liberation from the depot. The concentration in the plasma gradually increasing, reaching a peak at 6 days after injection, and then decreases with T_1/2 three weeks. Equilibrium plasma concentrations achieved after 3-4 Ingyektion.effectiven in patients resistant to other neirolepticski means. Has some aguirutee effect. The giperaktiveh children eliminates excess motor activity, behavioral disorders (impulsiveness, zatrudnennouu focus, aggressiveness).

Indications

206 initiation of different genesis (obsession, dementia, mental retardation, psihopatia, the acute and chronic schizophrenia, chronic alcoholism), and crazy hallucinations (paranoid condition, acute psychosis), trochaic Gentington, uncontrollable vomiting, psychosomatic violations behavioural disorders in elderly and children, abductions, the long-term maintenance and resistant to therapy vomiting and ikota.

Restrictions on the use of

Cardiovascular disease events decompensation, violations conductivity cardiac muscles and the kidneys.

Contraindications

Гиперчувствительност ь (including from other derivative butirofenon, kunjutnomu Oil), diseases of the central nervous system, causing pyramid and ekstrapiramidna symptoms, depression, hysteria, coma, pregnancy, breast-feeding (nursing mothers should stop breast-feeding), up to three years (for injecting).

Side-Effects

Headache, insomnia or sleepiness (especially at the beginning of treatment), the institution, anxiety, worry, fear, euphoria or depression, lethargy, had an epileptic seizure, exazerbation psychosis and hallucinations. A more long-term use, ekstrapiramidnye violations (more muscular stiffness, tremor, akinesia), incl. Later distonia and neirolepticeski malignant syndrome, accompanied gipertermiei, muscle rigidity, loss of consciousness. When used in high doses, giposalivation, nausea, vomiting, constipation or diarrhoea, arterial hypotension, tachycardia, incredible, ECG changes, and sometimes violating the liver up to the development of jaundice, and makulopapulezne akneobraznae skin lesions; Rarely visual impairment (including gravity), cataracts, retinopathy laringospazm, bronhospazm, pain in the chest glands, ginekomastia, the menstrual cycle, impotence, increased libido, urine retention, priapizm, sweating, alopecia, temporary or lakopenia leucocytosis, eritropenia, giperprolaktinemia hyper and hypoglycaemia, giponatriemia, photosensitization.

Patient interaction

Do effect antigipertenziveh preparations opioid analgesics, antidepressants, barbiturates, alcohol weakens indirect anticoagulants. Stops metabolism tricyclic antidepressants (increasing their level of plasma), and increases the toxicity. In a long carbamazepina level galoperidola plasma drops (to the IMF). In combination with lithium can cause symptoms similar to BSE.

Overdosing

Symptoms : expressed ekstrapiramidnye violations arterial gipotenzia, drowsiness, block, in the most severe cases, coma, respiratory depression, Shok.lechenie : specific antidote not. The scene stomach, the subsequent appointment activated charcoal (if overdose linked to the reception inside). When oppression breath-IVL, and expressed lower AD-introduction plazmozameshchath liquids, plasma norarenalina (but not miss!) , To reduce symptoms extrapiramidale disorders, central and holinoblokatora противопаркинсоничес кие funds.

Precautions

In developing psoriasis later that gradual reduction of dose (up to the complete abolition). During therapy patients should refrain from activities potentially hazardous activities that require increased attention rapid mental and motor reactions.

Dosing and Administration

In / in, in / m and inside. For acute psihozah adults ingeziruut 5-10 mg in / m or / with a possible one - or twice repeated insertion of the 40 minutes (maximum daily dose of 30 to 40 mg). In Puerto acute psychosis in / 5-10 mg (repeat as necessary) in the case of alcohol deliria in / 10-20 mg at a speed of 5-10 mg / Min.tabletki and solution for admission into adult appointed average daily dose of 2.25 to 18 mg, increasing it to be sustained therapeutic effect, leading to the lower supporting Doze.pri treating illness in children under five years of age start with two drops of solution for the reception inside twice a day for children older than 5 years, 5 drops twice a day, with the possibility of increasing doses to achieve the effect. In the absence of clinical improvement within 1 month to continue therapy is not recommended.

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