Levomepromazine

Chemical name

(R)-2-Метокси-N,N,бета-три метил-10Н-фенотиазин-10- пропанамин (as maleate (1:1) or hydrochloride)

Gross

C19-H24-N2-O-S

Characteristics

Jeltovato-bely slightly gigroskopicny powder. Sensitive to light and air. It is soluble in water, alcohol, chloroform; Nerastvorim almost on the air.

Of drugs

Drugs, the neuroleptic, antipsihoticescoe, analgezirutee, protivorvotnoe. Oppressing dofaminovu system mezolimbicescoy and mezokorticalna areas of the brain. Decreases productive symptoms psychoses - delirium, hallucinations, agitation. Has expressed adrenoblokirutmi, moderate holinoblokirutmi and antihistamines properties. Is jaroponijatuyu activity. Impact Ad.bystro and adequately absorbed in any of the introduction. C_max achieved after 1-3 h after administration of inwards and the 0.5-1.5 h after the / m injection. Passes through gistogematicalkie barriers, including GEB, and distributed in organs and tissues. Biotransformiroetsa intensively. The active metabolite - N-desmetilmono-metotrimeprazin, hereinafter becoming monosulfoxid. T_1/2 levomepromazina - 16-78 hours Return (including metabolites) in urine and jelchew.

Indications

206 initiation of different etiology, accompanied by fear, anxiety, anger, nervous breakdowns with increased agitation and violations of sleep, pain syndrome in the chamber troinicnogo and neurite facial nerve, fences aciclovir, zudaschie Medicine (combined), epilepsy, mental retardation (combined), premedikation (potentiation of analgesics, and antigistaminnah anaesthesia drugs).

Contraindications

Hypertension (especially older), chronic heart failure in the phase of decompensation, other cardiovascular and respiratory diseases, blood system, liver failure and kidney failure, jaundice, zakratougolnaya glaucoma, acute infections, epilepsy and parkinsonism, pregnancy and breast-feeding.

Side-Effects

Ekstrapiramidnaya symptom-dominated акинето-гипотоническ��го syndrome, fatigue, weakness, drowsiness, headache, ortostatical hypotension, tachycardia, tromboembolia, dry mouth, nausea, constipation, violations of the liver, disorders of menstruation, mejmenstruale allocation, mastalgia, agranulozitos.

Patient interaction

Do central depressive effects of drugs oppressive central nervous system, reduces противопаркинсоничес кую levodopa activity. Antihypertensive increase the risk Orthostatic hypotonia. Antatsida containing calcium, magnesium and aluminium, reduces the absorption of blood (levomepromazin be taken one hour before or within 4 h after administration antatsidnykh funds). Antiholinergicakie effects m-holinolitikami increase.

Overdosing

Symptoms : convulsions, Koma.lechenie : reanimatinaya and symptomatic treatment in a specialized hospital room.

Precautions

The change seats injection due to the potential for local tissue reaction. A systematic analysis of the blood and monitor liver function. To prevent collapse within 30 minutes after the injection to the horizontal position. Patients receiving levomepromazin should refrain from the use of alcohol and potentially dangerous activities (driving, machinery).

Dosing and Administration

Inside, in / m, / 386/1989 Severe case beginning with the injection of 75 mg, if necessary, up to 200-250 mg in / m, or 100 mg in / 386/1989 Gradually move the oral ingestion of 50 to 100 mg / day (if necessary up to 400). For heavily acute alcoholic psychosis-50-75 mg in / in, and then 150 mg in / m for 5-7 days. In outpatient facilities appoint 12,5-50,0 mg / day inside.

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