Olanzapine

Chemical name

2-Метил-4-(4-метил-1-пипе��азинил)-10Н-тиено[2,3-b][1, 5]бензодиазепин

Gross

C17-H20-N4-S

Of drugs

Drugs, the neuroleptic, antipsihoticescoe. Does the system dofaminergicakih neurotransmitters in bazalnah gangliah limbic, and the front part of the brain, has been working with the gistaminovmi H_1-, m-holino- and alfa_1-adrainoretseptorami, some subklassami serotonin receptors. Has sedative effect blunts severity of emotional experiences weakens aggressiveness and impulsiveness behaviour contributes to the development of tolerance to environmental validity and reduce personal initiative. ® excitation and corrigiruet behavioural and thought disorders in Psychotic Ballah.bystro and is absorbed in the blood, the time a C_max-6 pm Passes through gistogematicalkie barriers, including GEB. Biotransformiroetsa in the liver. Metabolites characterized by low pharmacological activity glukuronid not cross the GEB. T_1/2 ranges from 29 to 55 hours In eliminate drug involved kidneys in the urine, more than half the doses imposed in the form of метаболитов.Эффектив��н in patients with acute schizophrenia. productive reduces symptoms (delirium, hallucinations, thought disorder, hostility, suspicion), run negative symptoms (emotional cattle, intravertnosti, poverty speech).

Indications

Psychotic, incl. schizophrenia (Production and negative symptoms in acute form).

Contraindications

Hypersensitivity, the liver, epilepsy and the resulting high sudorojna readily mielosuprescia, mieloproliferativee disease gipereosinofilny syndrome, prostate adenoma cancer, paralytic ileus, zakratougolnaya glaucoma, pregnancy, breast-feeding (at the time of treatment excluded), Children and Youth age (up to 18 years).

Side-Effects

Drowsiness, dizziness, akatizia, giperprolaktinemia, increased body mass index, peripheral oedema, ortostatical gipotenzia, dry mouth, obstipation, ekstrapiramidnye violations, including diskinesia later, neirolepticeski malignant syndrome, holetsatical jaundice, tranzitornaya lakopenia, eozinofilia, transient increase in transaminaz, allergic skin reactions.

Patient interaction

Do devastating effect on the central nervous system ethanol takes effect drugs levodopa. Carbamazepine accelerates Cl.

Overdosing

Symptoms : nausea, drowsiness, sputannosti speech expressed midriaz, respiratory distress, hypotension, tachycardia, ekstrapiramidnye disorders (acute distonicescie muscular reaction, parkinsonism, akatizia). Treatment : stomach scene, the introduction of activated carbon, the maintenance of vital functions. When expressed arterial hypotonia recommended / cefuroxim in liquid and giving the patient Trendelenburga 1-2 hours; If necessary vazopressorna therapy should be used and noradrenalin fenilafrin and avoid showing appointments, which can worsen their mental state.

Precautions

An older patients and patients with severe liver disease and kidney initial dose should be reduced to 5 mg a day. During treatment precluded admission of alcohol. Be wary designate drivers and employees potentially hazardous activities that require greater attention and speed of reaction. When syndromic involving neirolepticeski malignant syndrome (fever, muscle tension, akinesia, tachycardia, leucocytosis, increased CPK) is the immediate withdrawal of the drug. Given the opportunity to develop akatizia, with the emergence of a treatment applied concern neusidchivosti, constantly try to move an unacceptable dose, on the other hand, showed declines, and the appointment противопаркинсоничес ких funds.

Dosing and Administration

Inside. Initial dose of 10 mg per day once. The increase in the dose th day administered, the range of daily doses 5-20 mg.

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