Periciazine

Chemical name

10-[3-(4-Гидрокси-1-пипери динил)пропил]-10H-фенот��азин-2-карбонитрил

Gross

C21-H23-N3-O-S

Of drugs

Drugs, the neuroleptic, antipsihoticescoe, sedative, protivorvotnoe. And adreno- and holinoliticaskoy activity protiwallergicakim and gipotermicski effects. Stage clearly expressed about злобно-раздражительн��го and gnevlivogo of passion. Reduced aggressiveness is not accompanied by the emergence of weak and delayed. Does postsinapticalkie dofaminergicakie receptors (mostly D_2-retseptora) located in mezolimbicescoy system (antipsihoticescoe effect), Hypothalamus (gipotermiceski effect galactorea), the action vomitoxin point ekstrapiramidna system. Perhaps the selective effect on D_2-dofaminove receptors have biotransformation products periciazina. It stops the release of mediators, reducing permeability presinapticakih membranes, violates its reverse takeover and deposit. The blockade of central and adrenergicakih serotoninergicakih structures is reduced fear, anxiety, stress, peripheral (adreno- and gistaminovykh H_1-retseptorov) - gipotenzive and protiwallergicakim action. Normalizes the behavior refers to his "proofreaders. Effective in human behaviour (especially in children), make contact with patients, and sometimes it ekstrapiramidnye Rasstroistva.horosho drawn from the blood. However, the first passage "through the liver after taking into concentration in the plasma are lower than those in the / m introduction, and, moreover, varies widely. In the blood of 90% is associated with plasma proteins. Intensive penetrates the tissues, as easily pass through gistogematicalkie barriers, including GEB. Metabolised in the liver (gidrauxilirovnie and algae), are liver recycling. T_1/2 is about 30 hours (off biotransformation products longer). Return with urine, and jelchew faeces, enters the breast milk.

Indications

Psychopathy (whobudimogo and istericeski type), psihopatopodobne of organic genesis-dominated asteniceski passion and behavioral psihopatopodobne state of schizophrenia (including giboidnye), paranoid state of the organic, vascular, and presinilnykh Senile diseases, with epilepsy аффективно-взрывчаты��и harakterologicakimi manifestations and distroficescimi states.

Contraindications

Zakratougolnaya glaucoma, porphyria, prostate adenoma cancer, chronic agranulozitos in history.

Side-Effects

Dejection, psoriasis : early (спазматическая wryneck, окуломоторный криз, тризм), and later, экстрапирамидные violations ортостатическая hypotension, dry mouth, constipation, paresis аккомодации whose urine, impotence, frigidity, аменорея, галакторея, гинекомастия, гиперпролактинемия, increased body mass index, hyperthermia, холестатическая jaundice, агранулоцитоз, photosensitization, allergic reactions.

Patient interaction

Do effects of tranquilizers, alcohol, analgesics, gipotenziveh, sleeping-and the means to narcosis.

Overdosing

Symptoms : parkinsonism, Koma.lechenie : symptomatic.

Precautions

In cases of gipertermii therapy ceased. Careful observation for the treatment of epilepsy (with regard to the possible lowering of the threshold epileptogennogo) and parkinsonizma. Be wary appoint older patients (gipotenzivny and sedative effects), and heart disease, kidney or liver failure, drivers transport and those working with potentially dangerous machinery, as there might be wasting, especially at the beginning of the course. Early diskinesia can kupirovtsa reception and antiholinergicakih противопаркинсоничес ких funds. These funds partially withdraws экстрапирамидный syndrome, but противопоказаны later in psoriasis.

Dosing and Administration

Inside (preferably in the evening hours). Starting with 5-10 mg, patients with high sensitivity - 2-3 mg 3-4 times a day. Average daily dose of 30-40 mg, the maximum for 50-60 mg.

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