Pimozide

Chemical name

1-[1-[4,4-бис(4-Фторфенил)б утил]-4-пиперидинил]-1,3- дигидро-2H- benzimidazol-2-on

Gross

C28-H29-F2-N3-O

Characteristics

The white crystalline powder. Nerastvorim almost in the water.

Of drugs

The drugs-antipsihoticescoe, sedative. And antiholinergicescoy and adrainoliticescoy activity. Antipsihoticeski effects from the indiscriminate interaction with the pre - and postsinapticakimi dofaminovmi receptor. Alleviate diskineticalkie disorders (propulsion and voice practice), with the syndrome Gilles de la Turetta.posle intake of rats 50%. The "first pass" through the liver is biotransformation, mainly by N-dezalkilirovania into two major active metabolites. C_max achieved through 6-8 hour T_1/2 is 29 hours (19-39 hours), in patients with schizophrenia-55 p considerable individual variation. Place in 1 hour, in the urine (50%) and faeces (20%). Step comes quickly, the greatest impact is in 2 hours, lasts for about six hours and passes through the 24-hour

Indications

Chronic schizophrenia (without symptoms ajitation, causing hyperactivity), the paranoid, psychotic and neurotic state with paranoidalnami signs syndrome Gilles de la Turetta.

Contraindications

Гиперчувствительност ь (incl. to neuroleptic etc.), Parkinson's disease, arrhythmia (including in history), the heavy oppression of the central nervous system and it komatosnye status, breast cancer (perhaps the prolactin concentration in the serum and degradation), the functional human liver and kidneys, gipokaliemia.

Side-Effects

Jeludockove adults, akatizia, ekstrapiramidnye effects (zatrudnennaya speech disturbance, maskobraznoe person sharkataya passive, slow movement, stiffness of arms and legs, shaking fingers and wrists), changing attitudes or behaviour distonicescie ekstrapiramidnye disorders (difficulty in swallowing, the inability to move the eyes, muscle cramps face, neck and back, izgibatesa the torso) persistirutaya later diskinesia (pricmokivanie and wrinkling lips, cheeks naduvanie, rapid movement cerveobraznae language, uncontrolled jaw movements), sore throat, bleeding and haemorrhage obturazionnaya jaundice, neirolepticeski malignant syndrome (convulsions, cough or frequent respiration, hyperthermia, unstable AD, increased sweating, involuntary urination), later distonia.

Patient interaction

Deprimirote means (including alcohol) increased oppression of the central nervous system and it holinolitiki - antiholinergicakie of (dry mouth, constipation and anxiety), Tricyclic antidepressants, dizopiramid, maprotilin, fenotiazin, procainamide, quinidine, the likelihood of arrhythmias. It increases the risk of extrapiramidale disorders in the face of doses.

Overdosing

Symptoms : drowsiness, dizziness expressed, coma, tremor, jerkiness, muscle stiffness, or severe uncontrollable movements, difficulty breathing, unusual fatigue or expressed weakness, ortostatical Gipotenzia.lechenie : induction vomiting or stomach scene, the road respiratory tract IVL, in / with the introduction of liquids, or plasma albumin concentration and sossoudossoujiwath flow, противопаркинсоничес ких products (including benstropina and Diphenhydramine).

Precautions

Be wary appoint patients older and children under 12 years of age (a correction dose), in violation of the functions of the liver and kidneys. For acute diseases Psychotic that treatment begin with the appointment of neiroleptika gipnosedativoy activity, and then gradually move to pimozida reception; It should be borne in mind that in the early days of therapy may increase the aggressiveness.

Dosing and Administration

Inside (before delivery). Adults - 1 mg once a day, and then gradually dose increase. The average daily intake of 5 mg (8 mg).

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