Pipotiazine

Chemical name

10-[3-[4-(2-Гидроксиэтил)-1- пиперидинил]пропил]-N,N -диметил-10H-фенотиазин -2-сульфонамид (and as palmitate or undetsilenata)

Gross

C24-H33-N3-O3-S2

Of drugs

Drugs, the neuroleptic, antipsihoticescoe, sedative. Does central dofaminove receptors inhibits sinapticescuu transfer to the brain. Decreases psihoticescuu symptoms and fear, aggressiveness, depersonlizatia, agitation block. Particularly effective in the form of paranoid schizophrenia, chronic psihozah with Galloucinatiami.posle intake of rapidly absorbed : C_max achieved in 1-2 hours Bioavailability is about 40%. T_1/2 - 4-5 days. Write largely through the intestine with the bile excretion; 5-10% excreted through the kidneys. Special product formulation (solution pipotiazida palmitate in the oil) is the gradual release of the active substance in the hydrolysis of palmitate in the introduction.

Indications

Chronic psychosis, or deficitarnaya of paranoid schizophrenia, gebefrenia, chronic galloucintorne and affeguo-bredove state. Acute psychosis and acute crises of chronic illness-maniakale attacks occurred nonsense, of the institution.

Contraindications

A toxic agranulozitos in history, zakratougolnaya glaucoma, porphyria, prostate disease, pregnancy and breast-feeding (at the end of treatment).

Side-Effects

Dejection, psoriasis is an early (spastical wryneck, okulomotornyi kriz, trism), and later, ekstrapiramidnye violations paresis ccomodation, ortostatical hypotension, agranulozitos, dry mouth, constipation, holetsatical jaundice, urine retention, impotence, frigidity, amenorea, galactorea, ginekomastia, giperprolaktinemia, increased body mass index, hyperthermia, photosensitization.

Patient interaction

Narcotic analgesics, protivokashleve means antipruritic drugs, barbiturates, benzodiazepines and clonidine added effect. Ters hypotension caused guanetidine. Antigipertenzivee drugs increase the risk of ortostaticski collapse.

Overdosing

Symptoms : acute syndrome parkinsonizma, Koma.lechenie : maintaining vital functions.

Precautions

When gipertermii treatment immediately cease. Careful monitoring of the patients with epilepsy (possibly lowering the threshold epileptogennogo) and parkinsonizmom. Be wary appoint older with heart disease, kidney or liver failure, drivers transport and those working with potentially dangerous machinery (possible drowsiness and reduced reaction, particularly at the beginning of treatment).

Dosing and Administration

Inside, in / m. Inside-1 once a day, usually in the morning; Initial dose of 10 mg, the average therapeutic dose-20-30 mg; If necessary, up to 60 mg in Sutki.ingyektion appointed after taking inwards. In / m deep (avoid suicide), first in a hospital environment, then out-25-200 mg (1 ml) once a Mexiaz.dla older patients and those with epilepsy BSE and alcoholism initial dose of 25 mg and increases with Neobhodimosti.detam, depending on the age-12,5-50 mg, with an increase to 100 mg.

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