Promazine

Chemical name

N,N-Диметил-10H-фенотиаз��н-10-пропанамин (and as hydrochloride or embonate)

Gross

C17-H20-N2-S

Characteristics

White or white with a yellow-brown crystalline powder. Easily soluble in water. Gigroskopichen. The light powder and aqueous solutions are sine-zelenuyu colour.

Of drugs

Drugs, the neuroleptic, antipsihoticescoe, sedative, protivorvotnoe. Decreases of psychoses : nonsense and hallucinations. He has also gipotenzive, protiwallergicakim and gipotermicski действием.Антипсихот��ческий effects linked to the embargo dofamine D_2-retseptorov in polineironalnah neurotransmission hemoretseptorna action of the brain. Oppression dofamine receptors in nigrostriarna and тубулоинфундибулярно й zones makes ekstrapiramidnye disorders and giperprolaktinemia, central and adrenergicakih serotoninergicakih receptors - reducing fear, anxiety or stress. Peripheric альфа-адреноблокирую��ий and H _1-гистаминоблокирующ��й effects are declining and AD protiwallergicakim Actiem.horosho absorbed after administration inwards. Connection with the plasma protein-90%. C_max is 2-4 hours Treated biotransformation in the liver with the formation of active metabolites. Excreted, mainly kidneys.

Indications

Disorders, schizophrenia, vomiting with chemotherapy and radiation therapy, malignant hyperthermia, porphyria.

Restrictions on the use of

Pregnancy. There is a need to stop breastfeeding at the time of treatment. Be wary drug use in children under 12 years of age.

Contraindications

Hypersensitivity, alcoholism, and the shock of komatosnye, organic defeat CNS disease, epilepsy, Parkinson's disease, ischemic heart disease, breathing problems, breast cancer, renal and hepatic failure, prostate adenoma cancer, and diseases of the blood, glaucoma.

Side-Effects

Ekstrapiramidnye disorders, catalepsy, declining motivation, headache, dizziness, diarrhoea events (nausea, vomiting, diarrhoea, pain in the abdomen, anorexia), holetsaticeski hepatitis, arterial hypotension, atony bowel and bladder, and photosensitization skin pigmentation, severe glaucoma, amenorea, galactorea, priapizm, agranulozitos, anaemia, allergic reactions.

Patient interaction

Enhance the effect of alcohol, tranquilizers, analgesics, tranquilizers and means to narcosis, as well as gepato- nefrotoksicnosti and medicines. Reduces activity and bromokriptina противопаркинсоничес ких products.

Dosing and Administration

Adults, inside and / m 10-100 mg every 12 hours The highest daily intake - 2 G.detam over 12 years in the 10-25 mg every 6 hours inside or / m. The highest daily intake - 1 and

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