Quetiapine

Chemical name

2-[2-(4-Дибензо[b,f][1,4]диаз епин-11-ил-1-пипразинил) этокси]этанол (and in the form of gemifumarata)

Gross

C21-H25-N3-O2-S

Of drugs

The drugs-antipsihoticescoe. Interfaces with serotoninovmi 5-ht_2-retseptorami (mostly), and D_1- D_2-dofaminovmi receptor, gistaminovmi receptor, and alfa_1- alfa_2- (less active) adrenoretseptorami Brain. Duration the 5-HA_2- D_2-retseptorami and is not less than 12 C.bystro and completely absorbed from the digestive tract and 83% associated with a protein of blood. 95% biotransformiroetsa to inactive metabolites, 73% of whom see kidneys, 21% through the intestine. T_1/2 about 7 p.m. Older patients metabolic Cl 30-50% lower than that of patients aged 18-50 years; 25% is reduced when heavy human liver and kidneys (Cl creatinine less than 30 ml / min).

Indications

Acute and chronic psychosis, including schizophrenia.

Pregnancy and lactation

Perhaps if the effect of therapy outweighs the potential risk to the fetus. At the time of treatment should stop breastfeeding.

Contraindications

Гиперчувствительност ь.

Side-Effects

From the circulatory system and blood (blood, gemostaz) : ortostatical gipotenzia, hypertension, tachycardia, Lakopenia.so the nervous system and sensory organs : drowsiness, dizziness, anxiety, rarely malignant neirolepticeski Sindrom.so the metabolism : increase in the level of cholesterol, triglycerides whey, ALT and AST, change in the level of liver Fermentov.so the stomach : dry mouth, diarrhoea or constipation, Dispepcia.so the skin : skin rashes, dryness Koji.prochie : pain syndrome (abdominalnaya pain, headache, in the lower back, muscles, chest, ear), fatigue, myalgia, infection urinary tract, fever, an increase in body mass index.

Patient interaction

Tioridazin, induktora system zitohroma P450 (eg, phenytoin) biotransformatia up.

Overdosing

Symptoms : drowsiness, and sedative effect, tachycardia, Gipotenzia.lechenie : symptomatic; Restoration and monitoring road upper respiratory tract ensuring adequate oksigenation and ventilation, monitoring and maintenance of the cardiovascular system.

Precautions

During treatment advised to refrain from work with the instruments and driving transport.

Dosing and Administration

Inside, two times a day. Daily dose increased from 50 to 300 mg in the first four days (50, 100, 200, 300 mg), and further support in the 300-750 mg / day, depending on the clinical effect. Older patients and the patients with liver and kidney initial dose of 25 mg, followed by an increase of between 25 and 50 mg per day to achieve effective levels.

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