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Rispolept

See also Risperidone

Roman name

Rispolept

The composition and the form of

1 tablet coated liner contains risperidona 1, 2, 3 or 4 mg; blistere in 10 pcs. , in box 2 and 6 blisterov.1 ml reception inside-1 mg; in vials to 30 or 100 ml complete with pipetkoy drugs, in one box set.

Pharmacokinetics

Once inside completely absorbed (regardless of the meal). C_max achieved in 1-2 hours Linking blood plasma (albuminom and alfa_1-kislotnam glikoproteinom) for the 88%. Quickly distributed infiltrates the central nervous system tissue, the distribution of 1-2 l / kg Metabolised partly with the formation of equal amount of activity 9-gidroksirisperidona, swyazawategosa with plasma protein by 77%, partly on the road N-dezalkilirovania. Equilibrium concentration achieved within 1 day 9-gidroksirisperidona for 4-5 days. T_1/2 to three hours, 9-gidroksirisperidona-24 p.m. After 1 week receiving 70% return with urine, 14% from faeces; 35-45% of the dose excreted in the form of active substances.

Farmakodinamika

Suppress delirium, hallucinations, automaticity, reduces fear weakens aggressiveness. Oppressing motor activity and produces katalepshiyu.

Indications

Schizophrenia and other psychotic state with a predominance of productive (crazy, hallucinations), negative and emotional symptoms, behavioral disorders in patients with brain, mania in bipolar disorders (secondary treatment), behavioral disorders in patients with delayed mental development or dominance in clinical picture destructive tendencies.

Pregnancy and lactation

Perhaps in pregnancy if the expected effect of therapy outweighs the potential risk to the fetus. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, breastfeeding, age and 15 years of age.

Patient interaction

Decreases effect of levodopa and dopamine antagonists. Fenotiazina, Tricyclic antidepressants and beta-adrenoblokatora can increase concentration in plasma.

Precautions

Be wary used in heart failure, myocardial infarct, violations conductivity heart, stroke, Parkinson's disease, epilepsy.

Storage conditions

List B. In the dark place at a temperature of 15-30 ° C

Shelf life

3 years

The registration

014824/01-2003

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