Sulpiride

Chemical name

5-(Аминосульфонил)-N-[(1-��тил-2-пирролидинил)ме��ил]-2-метоксибензамид

Gross

C15-H23-N3-O4-S

Of drugs

Drugs, the neuroleptic, antidepressant, psihostimulirutee. Specific blocks dofaminove D_2 and serotoninove receptors. Along with antipsihoticski also protivorvotnoe and kataleptogennoe act weakens fenamina effects. Impact on impulsaciu blujdatemu nervu increases irritative blood, improves blood circulation and accelerates recovery processes Tkaniah.pri ingestion quickly and completely absorbed, but the material does not exceed 35% (effect "of a" through the liver). The blood is associated with a protein of 40%. Easily passes gistogematicalkie barriers and reaching into all tissues (liver, kidney, brain, especially Gray, etc.), placenta and breast milk. In Injecting a C_max achieved through 30 minutes, oral-by 4.5 hours Penetrates the placenta and breast milk. Write mainly kidneys unchanged to clubockova by filtering (92%). The Cl (usually equal pochernmu) is 126 ml / min. T_1/2 about 7 C.effectiven against acute maniakalnah and maniakalno-bredovykh states; Provides fast and stable effect without creating sunk, sleepiness, emotional indifference. The operational in pathology, involving electricity, block, incl. and depression, schizophrenia low, clinically characterized by "regulatory" influence on the central nervous system. At doses of 600 mg / day to rastormaerveschee effect that over 600 mg - is antipsihoticescuu activity reduces symptoms productive.

Indications

Schizophrenia (including latent form, accompanied by sluggishness, block), acute and chronic psychosis dominated agrammatizma, abulia, confusion, saying the disease stomach and duodenal ulcers, migraines, dizziness, posttravmatical encephalopathy, a violation of the children themselves.

Contraindications

Hypersensitivity, feohromotsytoma, hypertension, the state of anxiety and psychomotor stimulation breastfeeding (for the period of treatment ceased).

Side-Effects

Insomnia, dry mouth, agitation early psoriasis (spastical wryneck, patients chewing muscles oculomotor violations), ekstrapiramidnyi syndrome, psoriasis later, and galactorea ginekomastia, menstrual irregularities, frigidity, impotence, increased body mass index, neirolepticeski malignant syndrome (hyperthermia, etc.), ortostatical hypotension.

Patient interaction

Do effect derivative morphine gistaminovykh H_1-blokatorov, barbiturates, benzodiazepines, clonidine and alcohol. Antigipertenzivee to increase the likelihood of Orthostatic hypotonia. Incompatible with levodopa (mutual antagonism). Sukralfat, antatsida (containing hydroxide Mg or Al) reduces bioavailability (by 20-40%).

Precautions

During pregnancy can be applied only to low-dose or long-term (mandatory control neurological symptoms). Be wary appoint patients with renal failure, epilepsy, parkinsonizmom, the elderly and the newborn, as well as people working with potentially dangerous machinery. During the therapy should not be driving. The take before use antatsidnykh funds.

Dosing and Administration

Inside, in the morning (no later than 16 hours) 2-3 reception. In psihozah for 1,600 mg a day for neurotic conditions for the 400 mg / day, with golovokrugenia-150-300 mg / day (rate is not less than 14 days), ulcer of stomach and duodenal ulcers, 150 mg per day; Daily intake for children is 5-10 mg / kg B / m-800 mg per day.

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