Sultopride

Chemical name

N-[(1-Этил-2-пирролидини��)метил]-5-(этилсульфон��л)-2-метоксибензамид (and as hydrochloride)

Gross

C17-H26-N2-O4-S

Of drugs

Drugs, the neuroleptic, antipsihoticescoe, sedative, protivorvotnoe, gipotermicescoe. Effectively resolves irritability, aggressiveness and agitation. Neirolepticeski effect of the blockade was dofamine brain receptors (mainly D_2). Is moderate antiserotoninovu and kataleptogennouu Aguosti.posle intake of rats rapidly and comprehensively bioavailability - 80-90%, C_max (dose 400 mg) is determined through two hours and the 3.7 mg / J After the / m of (200 mg) C_max 2-3 mg / ml, and the 25 minutes after the second dose, 3.5 mg / ml in 1 hour A linear dependence of the concentration of radiation. Equilibrium level in the plasma is on the first day of therapy. Many rapid (within 2 hours) and uniform penetration into tissue. Penetrates the GEB and placental barrier, in the breast milk (content sultoprida it twice as much armor). Biotransformation is more than 4% of the doses. Return with urine unchanged to (77-90%) and 10% from faeces. The Cl-390 ml / min, kidney Cl-325 ml / min. T_1/2 for 3-5 h not koumouliruet.

Indications

Acute and chronic psychosis (anxiety, the sense of violation, crazy, hallucinations, including in cases of schizophrenia), the aggressiveness and the institution (including Acute maniakalnom syndrome, chronic alcoholism).

Contraindications

Hypersensitivity, aetiology (less than 65 strokes per minute), feohromotsytoma (including suspected it), pregnancy, especially III Plus (to be reduced dose and reduce the length of the course, required follow-up of a newborn), breast-feeding (must stop breastfeeding), gipokaliemia.

Side-Effects

Block, drowsiness, psoriasis (early-spastical wryneck, trism oculomotor violations and later), ekstrapiramidnye disorders, convulsions, aetiology, ortostatical hypotension, giperprolaktinemia, amenorea, galactorea, ginekomastia, impotence, frigidity, the increase in body mass index, neirolepticeski malignant syndrome (hyperthermia, paleness, vegetative disorders).

Patient interaction

Do deprimirotee influence of narcotic analgesics, protivokashlevykh funds, barbiturates, tranquilizers, ethanol; , Taking levodopa-Mutual weakening effects. While tricyclic antidepressants increases the likelihood of later development diskinezi, fenotiazinov-human heartbeat rhythm, antigipertenziveh products, Orthostatic hypotonia. Side effects increase beta-adrenoblokatora, clonidine, heart glycosides, antiaritmiki I and III class gipokaliemia.

Overdosing

Symptoms : ventricular tachycardia, incredible, Parkinson's syndrome, Koma.lechenie : symptoms, the introduction of central holinoblokatorov.

Precautions

The caution used in epilepsy (possibly lowering the threshold epileptogennogo) parkinsonizme and heavy cardiovascular diseases, as increased risk of arterial hypotonia and cardiac arrhythmias. During the therapy of older patients increases the likelihood of excessive sedation and hypotension, sultoprid is intended to be used only in a hospital.

Dosing and Administration

Inside, in / m. In maniakalnah states in / m 400-1,200 mg / day in several varieties within 1-2 weeks, the maximum daily intake is 1,600 mg. Inside, 400-1600 mg / day, with the improvement in the dose reduced to 400 mg / day (if necessary treatment to low doses), to the institution heavily in / m 400-800 mg per day.

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