Thioproperazine

Chemical name

N,N-Диметил-10-[3-(4-метил-1 -пиперазинил)пропил]-10 H-фенотиазин-2-сульфон��мид (in the form of metanculfonata)

Gross

C22-H30-N4-O2-S2

Of drugs

Drugs, the neuroleptic, antipsihoticescoe, protivorvotnoe, sedative. Does postsinapticalkie dofaminove D_2-retseptora mezolimbicescoy in the brain, in тубероинфундибулярны х dofamine ways reduces products Zamf contributes to the release of prolactin and Development giperprolaktinemii selectively inhibits chemoreceptor launchers (trigger) a vomitoxin centre. Pair D_2-retseptorov in polineironalnah neurotransmission in the brain cause mild symptoms productive psychoses : nonsense and hallucinations. Antipsihoticescoe expressed by the stimulant (rastormazivatm) effect manifested propulsion Disorder. Impact on the nigrostriarnae, causing a phenomena parkinsonizma (with a predominance giperkineticeskih and diskineticakih disorders). In the long term can develop гиперчувствительност ь dofamine receptors leading to a slow symptoms psoriasis with horeoatetoidnami movements. Provides weak antiadrenergicescoe and antimuskarinovoe act occurs transient decrease AD and peripheral resistance vessels, as well as the higher Css.bystro and adequately absorbed in the digestive tract. Circulates in sossoudistom line in the form of protein (92-99%). Well soluble in lipids and easily passes through gistogematicalkie barriers, including GEB. Many high-volume distribution, but after the bioavailability intake of only 25-35% (effect "of a" through the liver). Treated biotransformation in the liver with the formation of active metabolites. Excreted in the kidney.

Indications

Schizophrenia (especially gebefrenica and continuously flowing katatonica form), chronic psychosis galloucintorne, maniakalny syndrome, stroke polymorphic nonsense.

Contraindications

A toxic agranulozitos in history, zakratougolnaya glaucoma, prostate adenoma cancer, parkinsonism.

Side-Effects

Vertigo, the combination of akinesia or giperkinesia high or normal muscular tone, extended diskinesia (with the long-term care), apathy, anxiety, mood swings, dry mouth, nausea, vomiting, constipation, diarrhea, oligouria, human heartbeat rhythm, paleness, tides blood slezo- and excessive salivation, paresis ccomodation, sweating, urine retention, impotence, frigidity, amenorea, galactorea, ginekomastia, giperprolaktinemia, increased body mass index, holetsatical jaundice, agranulozitos, photosensitization.

Specific guidance

In the late psoriasis reception antiholinergicakih противопаркинсоничес ких contraindications funds, as possibly worsening condition.

Patient interaction

Do gepato- and nefrotoksicnosti drugs alter effects (not recommended combine) levodopa, guanetidina, gipotenziveh drugs morphine antigistaminnah drugs, barbiturates, tranquilizers, atropine, alcohol.

Overdosing

Symptoms : expressed ekstrapiramidnye violations arterial gipotenzia, coma, respiratory depression, Shok.lechenie : symptomatic : IVL, the introduction plazmozameshchath liquids central and holinoblokatorov противопаркинсоничес ких funds.

Precautions

In developing gipertermii treatment immediately cease. During pregnancy should avoid long term use and reduce the dosage of birth; Monitoring the neurological symptoms and digestive system newborns. Drivers transport and persons working with, it should be borne in mind that the drug may cause drowsiness (especially at the beginning of therapy). Prudence required in the appointment of patients with epilepsy (falling sudorozhny threshold), the elderly (because of their high sensitivity), with the worst forms of cardiovascular disease, kidney and liver failure.

Dosing and Administration

Inside. Initial dose, 5 mg / day, followed by an increase of 5 mg every 2-3 days; Where appropriate daily dose of 30 to 40 mg per day. Dose for a / m introduction should not exceed 50% of the oral dose.

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