Thioridazine

Chemical name

10-[2-(1-Метил-2-пиперидин ил)этил]-2-(метилтио)-10Н -фенотиазин (and as hydrochloride or tartrate)

Gross

C21-H26-N2-S2

Characteristics

White or yellow crystal or powder mikronizirovanny odourless little or foul. Poor soluble in water, easy-to obezvojennom alcohol, it is all too easy in chloroform; PH 1% aqueous - 4,2-5,2.

Of drugs

The drugs-antipsihoticescoe, sedative. Dofaminergicescuu oppressing and adrenergic transfer, especially in the formation retikuliarna barrel brain, and removes its aguirutee impact on the reliability of large hemispheres and limbicescuu system. Antipsihoticescoe effect combined with protivorvotnam and sedative effects without development concerns delayed and emotional indifference. When endogenous depression is aguirutee and antidepressant effects. Does peripheral m-holinoretseptora and reduces more active autonomic nervous Sistema.pri ingestion absorbed quickly and adequately. Easily passes through gistogematicalkie barriers, including GEB through. Biotransformiroetsa to active metabolites mezoridazina and sulforidazina, T_1/2 about 16 hours

Indications

Acute shizofrenicescie syndromes, chronic schizophrenia, obsessive-endogenous depression, the mental institute different genesis; Neuroses accompanied by voltage excitation, unacceptable conditions and a sense of fear, policies, the withdrawal syndrome in toxicomaniah and chronic alcoholism.

Contraindications

Hypersensitivity, acute depression, komatosnye condition, severe diseases of liver, central nervous system and cardiovascular system, pregnancy, breast-feeding (at the time of treatment should be discarded), a children's age (up to 4 years).

Side-Effects

Drowsiness, parkinsonism, etc. ekstrapiramidnaya symptoms, lethargy, anxiety, agitation, psychotic reactions, headache, ECG changes, impaired vision, dry mucous membranes mouth, nausea, vomiting, constipation, diarrhea, paleness, galactorea, bloating mammary glands, amenorea whose ejaculate, peripheral oedema, refers, swelling glands glands, kozhno-allergicakie type of Urticaria.

Patient interaction

Incompatible with adrenalinom and anestezirutmi means guanetidine, rezerpinom. Do psychological effect, analgeziruth, drugs and alcohol weakens - levodopa and amphetamine. Amitriptyline and antipruritic drugs increase antiholinergicescuu activity antidiabetics the better the chance of liver damage.

Precautions

Periodic monitoring of the movements of peripheral blood. Be wary appoint older patients because of the risk of paradoxical reactions. The reception is not recommended driving and work with complex mechanisms. Revenue alcohol.

Dosing and Administration

Inside. Adults in outpatient treatment in the lungs cases, 10-25 mg 2-4 times a day in hospital, and more severe cases, 300-600 mg / day in a few receptions. Children 4-7 years, 10-20 mg / day, divided dose at the reception 2-3, 8-14 years, 20-30, 15-18, 30-50 mg / sut. Treatment is the steep drop dosage.

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