Tiaprida injection 5%

Roman name

Solutio Tiapridi pro injectionibus 5%

The composition and the form of

1 ml solution for injection contains tiaprida hydrochloride 0.05 g; 182,000,000 in 2 ml; in the paper cartons 10 vials complete with ampulnam nojom.1 tablet-0.1 g; in a contour acheikova packing 10 pcs. , in a cardboard paper packaging 3

Of drugs

Antipsihoticescoe, anxiolytic, analgezirutee. Selectively blocking D_2 -dofaminove receptors, improves cognitive function in old age.

Pharmacokinetics

C_max (2.5 µ g / ml) is achieved within 30 min. Rapidly (less than 1 hour) distributed in the body. Penetrates the GEB and placental barrier. It binds to plasma proteins, poorly sorbed with the cell. Slight metabolised, presented with urine unchanged to 70%.

Indications

Mental and behavioral disorders in dementia senilna and alcoholism; Ekstrapiramidnye violations nekupiruemy intense pain syndrome.

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, feohromotsytoma, pregnancy, breast-feeding.

Side-Effects

From the nervous system and sensory organs : neirolepticeski syndrome (akatizia, spasticskie reactions, muscle rigidity), drowsiness, and later diskinesia, somatovegetativee Narushenia.so the metabolism : amenorea, galactorea, ginekomastia, Giperprolaktinemia.prochie : ortostatical gipotenzia, increased body mass index, impotence, frigidity.

Patient interaction

Do the narcotic analgesics, H_1 -antigistaminnah drugs, barbiturates, tranquilizers, клонидина.Гипотензив��ые to increase the risk of developing Orthostatic Hypotension.

Overdosing

Symptoms : acute neirolepticalkie reaction hyperthermia, the consciousness Koma.lechenie : lifting drug symptomatic therapy (including appointment antiholinergicakih products), plazmaferez.

Precautions

Be wary appoint older patients (risk of sedative and gipotenzivnogo action), and epilepsy (possibly lowering the threshold sudorojna activity), heavy heart disease, kidney failure and Parkinson's disease. Avoid the simultaneous application of levodopa. During treatment should refrain from driving and other activities requiring more concentration.

Dosing and Administration

V / m or / 386/1989 Adults with deliriosnom and predeliriosnom state : give every 4-6 hours daily intake - 0,4-1,2 g; If necessary, the daily dose can be increased to 1.8 G.pri hard bolevom syndrome : 0.2-0.4 g / Sut.detam over seven years : 0.1-015 g / day, as appropriate dose can be increased; maximum daily intake 0.3 G.u patients with renal insufficiency with Cl creatinine 11-20 ml / min dose reduced twice less than 10 ml / min, 4 Raza.vnutri (before delivery). The motor disorders : 0.3-0.8 g / day, conduct disorders : adults, 0.2-0.3 g / day for 1-2 months (possible re-course), children over 7 years - 0.1-015 g (0.3 grams) per day; Nekupeerootesa pain, 0.2-0.4 g / sut.

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