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Tiapridal

See also Tiapride

Roman name

Tiapridal

The composition and the form of

1 tablet contains delimaya tiaprida hydrochloride 100 mg; blistere in 10 pcs. , in a box two blister.1 USD 2 ml solution for injection, 100 mg; in blistere 6 pcs. , in box 2 blisters.

Pharmacokinetics

After the / m injection 200 mg C_max (2.5 µ g / ml) is defined in 30 minutes, after receiving 200 mg inside (1.3 µ g / ml), in 1 hour Bioavailability 75% (reception immediately before the food enhances bioavailability of 20% C_max by 40%). Absorption in older people down. The quick : only a one hour is in many tissues and organs, a GEB and placental barrier, enters the breast milk (concentration in the milk of one half in plasma). There is not associated with blood plasma cell. T_1/2 2.9 hours for women and 3.6 hours for men. Moderately metabolizmu are : 70% of the doses found in the urine in an unmodified form. Breeding occurs mainly kidneys; Cl is 330 ml / min. In patients with human excretory functions of the renal excretion downward correlated with the amount Cl creatinine. Daily dose of the Cl creatinine less than 20 mL / min should be reduced to $ 1.3 billion, less than 10 ml / min were created.

Farmakodinamika

Provides antipsihoticescoe and anxiolytic effects, including in the treatment of alcohol, opiate and nicotine abstinence. Alleviate psoriasis, promotes clarity of thinking that the elderly patients who have analgeticakimi properties.

Indications

Conduct disorders (agitation aggressive), especially in patients with alcoholism; Pain (intensive, nekupirutayasa); Diskinesia (spontaneous, later, trochaic Gentington).

Pregnancy and lactation

Contraindicated. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, feohromotsytoma (including estimated), pregnancy, breast-feeding.

Side-Effects

With long-term use at high doses can sometimes drowsiness, and muscle hypotension, diskinesia (early-spastical, wryneck, trism oculomotor violations; And later), ekstrapiramidnye symptoms miorelaxation, demotion AD amenorea, galactorea, giperprolaktinemia, ginekomastia, impotence, frigidity, the increase in body mass index, neirolepticeski malignant syndrome (inexplicable hyperthermia requires the preparation).

Patient interaction

Incompatible with alcohol and levodopa. Could enhance effects of drugs oppressive central nervous system, as well as ACE inhibitors and other gipotenziveh funds.

Precautions

Be wary appoint epilepsy patients, severe heart disease, kidney disease, Parkinson's disease in old age, the newborn; While the drivers of vehicles and people skills relate to the high concentration of attention. There should be continuous surveillance with a combination of funds oppressive CNS, hypotensive drugs, including ACE inhibitors.

Dosing and Administration

Inside with motor problems on the 300-800 mg / day; Problems with the behaviour-adult-to 200-300 mg / day for 1-2 months, as appropriate course repeat; Children over the age of 7 years in the 100 and 150 mg / day in the 2-3 admission, as appropriate dose increase to 300 mg / day; nekupirutayasa pain is 200-400 mg / day inwards or contents 2-4 in vials / m or / 386/1989 In deliriosnom (predeliriosnom) - in / m or / every 4-6 hours in a daily dose-400-1,200 mg (up to 1800 mg) (contents vials 4-12). Daily doses reducyrovtsa depending on Cl creatinine.

Storage conditions

List B. In the dark place at a temperature of 900 ° C

Shelf life

5 years

The registration

008727

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