Tiapride

Chemical name

N-[2-(Диэтиламино)этил]-2 -метокси-5-(метилсульф��нил)бензамид (as hydrochloride)

Gross

C15-H24-N2-O4-S

Characteristics

Neiroleptik atypical from the benzamidov substituted. White or white with a yellowish sheen crystalline powder. Easily soluble in water, not in ethanol.

Of drugs

Drugs, the neuroleptic, antipsihoticescoe, analgezirutee, nursing, sedative, anxiolytic. Selectively blocking dofaminove D_2-retseptora mezolimbicescoy and mezokorticalna systems (D_1-retseptora a little). Sedative effect of the blockade adrenoretseptorov retikuliarna formations barrel brain; Protivorvotnoe-blockade D_2-retseptorov trigger a vomitoxin centre; Gipotermicescoe-blockade dofamine receptors гипоталамуса.Устраня��т psoriasis central origin. Suppress productive symptoms, including with organic diseases brain. Improves cognitive function in older patients. Has expressed analgezirutee up at intero- and exteroretseptivna pain. Potenziruet the other neiroleptkov not increasing ekstrapiramidna symptoms. Can lowering the threshold sudorojna activity in patients Epilepsiei.pri ingestion rapidly absorbed, eating reduces removals. C_max when administered achieved through one hour after the / m injection dose of 200 mg, 30 mines, and is 2.5 µ g / J The blood almost no contact with the squirrels, weakly associated with the cell. Quickly (in less than one hour) distributed in many tissues and organs, passes through GEB and gematoplatzentarnyi barrier. Moderately is biotransformation : 70% rate found in the urine in an unmodified form. T_1/2 is 2.9-3.6 hours Report the news. If any excretory functions of the renal excretion reduction relates to the value of creatinine clearance.

Indications

Giperkineticeski and diskineticeski syndrome (vascular origin, later psoriasis, Turetta syndrome, a severe and chronic trochaic, including trochaic Gettington, nerve TRT), tremor, headache neirogennogo origin, expressed pain syndrome, psychomotor imbalance / arousal, including in old age, conduct disorder (reactive, in old age, alcoholism, including aggressiveness), acute alcohol psychosis with wegetativei violations withdrawal syndrome in patients with alcoholism and drug addiction.

Restrictions on the use of

Epilepsy expressed kidney failure, Parkinson's disease, severe cardiovascular disease.

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should abandon breastfeeding.

Contraindications

Hypersensitivity, incl. other derivative benzamida, feohromotsytoma (including estimated), pregnancy, breast-feeding.

Side-Effects

From the nervous system and sensory organs : fatigue, drowsiness, agitation later diskinesia acute neirolepticeski syndrome (akatizia, spasticskie reaction trizm oculomotor violations rigidity of muscles, etc.), neirolepticeski malignant syndrome (hyperthermia to 40 ^ C, generalized muscle rigidity, somatovegetativee violations). From the urogenital system : amenorea, galactorea, giperprolaktinemia, ginekomastia, impotence, Frigidnosti.prochie : ortostatical gipotenzia, increased body mass index, skin allergic reactions.

Patient interaction

Compatible with neiroleptikami, anxiolitikami, antidepressants, and analgetikami neirotropnami other means. Do not combine (the increases) with opioidnami analgetikami, barbituratami, anxiolitikami, antihistamines means Clonidine. Together with a hypotensive means, including ACE inhibitors, increases the risk Orthostatic Hypotension. Incompatible with alcohol and levodopa.

Overdosing

Symptoms : acute or neirolepticeski malignant syndrome (ekstrapiramidnye disorders, hyperthermia), violations of consciousness until Koma.lechenie : lifting drug, and the appointment holinoliticakih of symptomatic therapy, plazmaferez.

Precautions

During treatment prohibited driving vehicles, servicing arrangements and other jobs requiring more concentration.

Dosing and Administration

Inside, in / m. Motor disorders : 300-600 mg / day, 2-3 reception. Jet with the motor either : 600-1200 mg / sut. Alcoholism, headaches : 200-400 mg / sut. After therapeutic effect reduce the dose to 200 mg / sut. Patients older 200-300 mg per day, if necessary dose increase. Daily intake for adults with the / m imposing 400 mg. Psychomotor imbalance, brain policies : children 7-12 years, 50 mg 1-2 times a day. In klirense creatinine 11-20 ml / min daily dose should be reduced by half, less than 10 ml / min, four.

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