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TizercinSee also LevomepromazineRoman nameTisercinPharmacokineticsOnce inside C_max plasma achieved after 1-3 h after the / m introduction-by 0.5-1.5 h Actively metabolised in the liver. Metabolite formed by demethylation has pharmacological activity, the remaining inactive metabolites. T_1/2 unchanged substances, 16-78 hrs Return with urine and faeces mostly in the form of metabolites.Indications206 initiation of different etiology (in acute and chronic schizophrenia, маниакально-депресси��ном psychosis, presenilnykh, Senile, intokshikaih and other psihozah, mental retardation, epilepsy), border mental illness (with alarm, panic, phobias, �бсессивно-компульсив ным syndrome resistant insomnia), potentiation of analgesics, of narcosis, antigistaminnah drugs.Pregnancy and lactationContraindicated in pregnancy. At the time of treatment should stop breastfeeding.ContraindicationsHighly arterial gipotenzia (especially in patients older), liver disease, blood system, chronic heart failure (including in the phase of decompensation), pregnancy, breast-feeding.Patient interactionIncompatible with MAO inhibitors (increased risk extrapiramidale disorders due to lower drug manufacture in the liver), and hypotensive drugs (excessive loss AD). Do sedativuyu and m-holinoliticescuu activity benzodiazepines, rape of analgesics, general anesthetics, and tricyclic antidepressants. Ters effectiveness levodopa. When coupled with the appointment of m-holinoblokirutmi being undesirable antiholinergicakie manifestations.PrecautionsWith the utmost care appoint patients with pathological changes in the blood picture, if there is a violation of the liver, cardiovascular diseases predisposing to the development of glaucoma, alcohol intoxication syndrome Rayee, breast cancer, Parkinson's disease, ulcers stomach and duodenal ulcers, delayed urine, chronic diseases of the respiratory system (especially for children), pripadkah seizures, the elderly and the weak. The change seats injection due to the potential for local tissue reaction to the introduction of the drug (in / m painful injections). When gipertermii product should be lifted immediately. The systematic analysis of the blood and the liver, the elderly and handicapped patients needed to be monitored AD. During the first 3-5 days of treatment after taking levomepromazina irrespective of the dose and mode of the patient should be 1/2-1 hours, in order to prevent ortostaticski collapse. Sometimes, with the rapid increase doses, particularly in the elderly or in patients with vascular insufficiency may develop drug deliri. The use during the drivers of vehicles and people skills relate to the high concentration of attention, requiring abandonment of alcohol.Storage conditionsIn the dark spotShelf life2The registration012432/01-2000 |
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