Trifluoperazine

Chemical name

10-[3-(4-Метил-1-пиперазин ил)пропил]-2-(трифторме тил)-10H-фенотиазин (and as hydrochloride)

Gross

C21-H24-F3-N3-S

Characteristics

White or slightly sulphur crystalline powder. Rat in the water and alcohol on the light solutions age.

Of drugs

The drugs-antipsihoticescoe, neuroleptic, psihostimulirutee. Dofaminove blocking receptors in the central neurotransmission, and nigrostriarnah тубулоинфундибулярны х Navigation. And antise 13ef7 rotoninova and adrainoliticescoy activity. Provides katalepticeski, gipotenzivny, protivorvotny, protivojikotny, gipotermiceski and giberniruty effects. It giperprolaktinemia. If ingestion is not absorbed completely. C_max is 2-4 h, and in / m introduction-in 1-2 hours The plasma is associated with a protein of 99%. Penetrates the GEB. Metabolised in the liver. T_1/2 is 15-30 hrs, Excreted aired mostly in the form of metabolites.

Indications

Disorders, schizophrenia, and galloucintorne delirium, agitation, vomiting central genesis.

Contraindications

Diseases of the liver, kidneys, blood, heart; Pregnancy.

Side-Effects

Ekstrapiramidnye disorders, liver failure, agranulozitos, allergic reactions (skin).

Patient interaction

Do effects of alcohol, pills, tranquilizers, narcotic analgesics.

Dosing and Administration

Inside, in / m. Initial dose is 1-5 mg / day in the reception 2-4, and then gradually increase (up to the desired effect). The maximum daily dose of 120-mg. The / m being 1-2 mg 4-6 times a day.

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