Zyprexa

Roman name

Zyprexa #

The composition and the form of

1 tablet coated liner contains olanzapina 5; 7.5, or 10 mg; in blistere 7 pc. , in box 4 blisters.

Of drugs

Antipsihoticescoe. As a ligand serotonin (2A/2C, 3, 6), dofamine (D_1-D_5) m-holino- (m_1-m_5) gistaminovykh H_1- and alfa_1-adrainoretseptorov selectively affects limbicescuu system.

Pharmacokinetics

Well drawn, C_max plasma through 5-8 hours Metabolised in the liver (on kongugatinomu and oxidative pathways) to inactive metabolites. The ethyl-- 10-n-glukuronid not pass through GEB. Average T_1/2 rates (depending on age and sex) in the 21-54 pm

Indications

Acute schizophrenia and other psychoses, accompanied expressed positive (delirium, hallucinations, thought disorder, hostility, suspicion), and / or negative (prituplenny passion, emotional and social otgorojennosti, poverty speech) symptoms. Secondary schizophrenia symptoms in the face of schizophrenia and related disorders.

Pregnancy and lactation

The appointment during pregnancy should be closely related alleged benefit to the mother and the risk to the fetus. During lactation nursing mothers should stop breast-feeding.

Contraindications

Гиперчувствительност ь.

Side-Effects

Frequent (more than 10%), drowsiness, and the increase in body mass index; Rare (less than 10%), dizziness, dry mouth, constipation, peripheral edema, hypotension ortostatical, akatizia, dystonia, eozinofilia (asymptomatic), a small and temporary increase in the level of prolactin (ginekomastia, lactorea) activity transaminaz liver.

Patient interaction

Ters effects of levodopa and dopamine agonists. Activated carbon material decreases by 50-60% oral. Smoking and carbamazepine up metabolism. Not revealed apparent interaction with antatidami, zimetidine, imipraminom, varfarinom, diazepam, lithium, theofillinom, biperidenom.

Overdosing

Symptoms : nausea, sputannaya speech, drowsiness. Midriaz, respiratory depression, hypotension, ekstrapiramidnye disorders observed in the experiments at Zivotnykh.lechenie : specific antidote not. Treatment of symptomatic, on the mandatory use of activated carbon, maintaining good ventilation and light oxygen saturation; In the case of collapse, in / in a norarenalina (but not with adrenomimetikov beta-stimuliruta activity-adrenaline, dofamin etc.).

Precautions

Assign with caution in patients with prostate overdetermination, zakratougolna glaucoma, paralysis intestinal bacteria, the convulsions fortunes of the disease, liver disease and kidney failure; In patients with haematological modified indicators; As well as in combination with other means, oppressive central nervous system (including the alcohol). Is not recommended at the time of treatment to manage the potentially dangerous machinery (vehicles, etc.).

Dosing and Administration

Inside, regardless of the meal. Initial dose is 10 mg per day, once. The daily intake can vary from 5 to 20 mg / day, depending on the clinical condition.

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