Zuclopenthixol

Chemical name

4-[3-(2-Хлор-9Н-тиоксанте��-9-илиден)пропил]-1-пип��разинэтанол

Gross

C22-H25-Cl-N2-O-S

Of drugs

Drugs, the neuroleptic, antipsihoticescoe, sedative. Does the system dofaminergicakih CNS neurotransmitters mostly bazalnah gangliah and limbic part of the front Mozga.biodostupnosti is about 45%. Medicines for a / m at the fermentativomu split allocating the active ingredient. C_max is : when administered through 6700, in / m in a 36 h in / m introduction depo-forma within seven days. Metabolised in the liver with the formation of active metabolites, excretiruthan mainly Jelchew.naibolee expressed Psychotic suppression of the in patients with disturbed behaviour. Between inicialna therapy expressed dozozawisimy Baby sedative effect.

Indications

Acute and chronic schizophrenia and other psychotic disorders with hallucination, paranoid illusion, a violation of thinking, behavioral changes reactions (of ajitation, increased anxiety, hostility, aggressiveness), maniacal phase ticlotimii, mental retardation, combined with behavior disorders, dementia senilnoe with paranoidalnami ideas sputannostew consciousness, disorientation, human behaviour.

Contraindications

Acute alcohol poisoning, barbituratami, opiates, coma, sudorozhny syndrome, chronic hepatitis, heart disease, the disruptions to the heart, pregnancy, breast-feeding (for the period of treatment to a breast-feeding).

Side-Effects

Ekstrapiramidnye violation (distonicescie acute muscular reaction parkinsonopodobnyy syndrome), later diskinesia (repeated automatic traffic lips, tongue, limbs, torso), drowsiness, dizziness, dry mouth, a breach of ccomodation whose urination, constipation, tachycardia, ortostatical gipotenzia, raising cium, transaminaz, neirolepticeski malignant syndrome (muscle rigidity, hyperthermia, leucocytosis, culinary dysfunction, human consciousness).

Patient interaction

Potenziruet deprimirotuyu activity barbiturates, tranquilizers, alcohol, glycine, etc. Metoklopramid piperazine and increases the likelihood of development extrapiramidale disorders. Reduces effective levodopa, etc. adrenergicakih substances. Ters gipotenzivne guanetidina effect.

Overdosing

Symptoms : increased drowsiness, and the sense of violation, up to the coma, sudorozhny syndrome expressed ekstrapiramidnye violations decline AD violations Termoregulyation.lechenie : the speedy and complete removal nevsosavchegosa preparation of the blood, monitoring vital targets symptomatic therapy.

Precautions

In chronic liver problems designate smaller doses. Be wary apply Elevated sudorojna preparedness. The muscle and distoni parkinsonizma required dose reduction and destination противопаркинсоничес ких funds. During treatment precluded admission of alcohol. Is not recommended to drive and work in the workplace associated with increased risk. To prevent the development of the syndrome doses should be reduced gradually.

Dosing and Administration

Inside, in / m. Dose selected individually. In acute schizophrenia and other severe mental disorders expressed ajitation, 10-20 mg / day, further dose can be gradually increased to 75 mg / day (several receptions). In chronic mental cases, 20-40 mg / sut. Violations of the mentally retarded patients, 6-20 mg / day (up to 40 mg / day). In ajitation and confusion in patients with schizophrenia senillnam, 2-6 mg / day of the evening (to 10-20 mg / day). In the early stages of treatment of acute illness on a / m-150 mg, and the lack of efficiency of a single-repeated injections usually within 2-3 days, but not less than a day; in a couple of days after the final injection shows shift to ingesting or immediately after the final injection, a depo-forma in / m in the dose of 200-400 mg repeated injections every two weeks.

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