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Zerebrolizin

Roman name

Cerebrolysin

The composition and the form of

1 ml aqueous solution for injection contains 215.2 mg concentrate zerebrolizina (of peptides derived from the brain pigs); USD in 1, 5 or 10 ml, in a box 10 and 5 vials respectively, in vials of 30 ml, in a Box 1, or 5 bottles.

Characteristics

Active fraction zerebrolizina the peptides, molecular weight of less than 10,000 Dalton.

Pharmacokinetics

The complexity of Zerebrolizina active fraction which consists of a balanced and stable mixture of biologically active cells with polyfunctional cumulative effect, which does not allow for a normal farmakokineticeski analysis of individual components. In these circumstances, some idea of farmakokinetike Zerebrolizina can only indirectly. It has been observed that after a single injection neirotrofica specific activity plasma can be maintained for 8 hours

Indications

Chronic cerebrovascular insufficiency (discirkulatornaya encephalopathy), ischemic stroke, traumatic brain injury (brain, brain damage, the condition after surgery for brain), delayed mental development in children; Disorders related to the lack of attention to children; Syndromes dementia different genesis (presenillnaya-Alzheimer's, senillnaya alzgeimerovsky type capillary - multianfarctnaya form mixed); endogenic depression, rezistentnaya to antidepressants.

Pregnancy and lactation

The caution (especially in the first trimester of pregnancy).

Contraindications

Pregnancy, serious violations of the kidneys, allergic diateza. Is not compatible with the solution of amino acids.

Side-Effects

Hypersensitivity, hyperthermia (in the face of rapid on / in Infusion).

Specific guidance

The caution should be appointed in preparation allergic diatezah large pripadkah convulsions.

Patient interaction

Do antidepressants effect.

Overdosing

Currently, the cases of drug overdose Zerebrolizin were reported.

Precautions

Be wary when appoint diatezah allergies, epilepsy.

Dosing and Administration

Every day, in / m or / in the drip. For acute conditions (ischemic stroke, brain damage, complications of neurosurgical operations), in / for a period of 60-90 minutes 10-60 ml in 60 ml of physiological solution; Course duration : 10-25 days. In reziduhalnom period stroke and traumatic brain damage in / in-5-10 ml within 20-30 days. In Alzheimer's disease, vascular dementia and dual genesis recommended dose is 20 to 30 ml in 200 ml of physiological solution, the course of treatment-20 infusions. In psihoorganicescom syndrome in / in the 10 ml, over a period of 20-25 days (Dementia), or 15 days (depression). In neiropediatricescoy practice for the 1-2 ml (1 ml per 10 kg) in / m, for 1 month, with a repetition rate of three times per year.

Storage conditions

List B. In the dark place at a temperature of no higher than 25 ° C

Shelf life

5 years

The registration

013827/01-2002

Literature

1. Piswanger A. et al. (1990). Modulation of protein synthesis in a cell-free system from rat brain by Cerebrolysin during development and ading. Amino Acids : Chemistry, Biology and Medicine, 651-657. 2. E. Ruther et al. (1994). Efficacy of the peptidergic nootropic drug Cerebrolysin in patients with senile dementia of the Alzheimer's Type (SDAT). Pharmacopsychiatry, 27, 32-40.

Of drugs

Is the metabolism of brain tissue. Zerebrolizin contains biologically active amino acids and peptides, the major components of cerebral metabolism (metabolism). Entered through the blood-brain barrier (the barrier between the blood and brain tissue), regulates drug vnutricletocny exchange, and improves sinapticescuu. transfer (of nervous institute). As a result of its increased efficiency aerobic energy metabolism (educational energy in the body in the presence of oxygen), improving vnutricletocny fusion protein decreases the negative impact lactatsidoza (acidity because of excessive lactic acid). This effect, combined with the stimulation of transsinapticescoy provides neiroproteguoe (protecting brain cells), the product, and thus to increase neuronal survival (brain cells) in hypoxia (insufficient supply of oxygen to tissues or interfere with digestion), and other damage effects.

Indications for use

Diseases of violating the central nervous system (encephalitis / inflammation of the brain), a breach of cerebral circulation, operations on the brain, mental retardation of children, mental illness, violent dispersion, less memory, etc.

Form of

In 182,000,000 to 1 and 5 ml of 5% solution.