Ethylthiobenzymidazol hydrobromide

Chemical name

2-Этилтиобензимидазол а gidrobromid

Characteristics

White or white with blue polka crystalline powder. Rat in the water (with the formation mutnogo solution), and ethanol.

Of drugs

The drugs-antihypoxia, psihostimulirutee, anxiolytic, antiastenicescoe. Increases sustainability of organs and tissues to hypoxia. It stimulates the brain, mental and physical activity, fitness and physical work, the physical strength and fosters faith normalizes attention. Psihotroponaya extends to psihostimuliruuschem and trankviliziruuschem action. The border mental disorders psihostimuliruty effect was to improve the fitness and mood, trankviliziruty in reducing anxiety and emotional strain. Antiasteniceski effect with a single and re-use. Is immunostimulirutuyu activity when used in combination with other means to treat retidiviruta Roji.posle single intake of the dose of 500 mg is rapidly absorbed from the gastrointestinal (average duration poluvsasavania 0.45 at C_max (0,82-6,6 µ g / ml) is two hours, with an average of 4% imposed doses. After two hours solid phase ends and the renewal phase distribution (rapid decline concentration in the blood), continuing at 4-6 plasma level at a terminal station kinetic curve of 0,38-1,07 g / J Some patients through 6700 is a second, less pronounced peak concentration in the blood. The others monoeksponencialnaya kinetics out. Prevailing (psihostimuliruty or trnkviliziruty) type of psychotropic specifics pharmacokinetics. The more C_max, AUC and less T_1/2, the more likely a aguirutego effect. In patients with psihostimulirutego dominance of the main farmakokineticeskih parameters are : C_max - 5.71 + 0.5 µ g / ml, AUC - 68.49 + 11.6 µ g / ml / min, T_1/2 - 13.72 + 1.6 p, Cl-8.5 + 1.9 ml / h. At the lower values C_max, AUC and extension T_1/2 spectrum of psychotropic activity increasingly prevalent trankviliziruty component. The C_max reaches 1.79 + 0.2 µ g / ml, AUC - 25.94 + 4.2 µ g / ml / min and T_1/2 - 32.08 +7.0 hours

Indications

Seven, including astenodepressivee organic disorders; neurozopodobne status, lowering efficiency due utomlemostew, labilnostew emotional impact of adverse external factors, the period of convalescence after craniocerebral trauma of cerebral circulation, operations.

Restrictions on the use of

Pregnancy.

Pregnancy and lactation

When pregnancy is possible only when absolutely necessary, if the effect of therapy outweighs the potential risk to the fetus.

Contraindications

Hypersensitivity expressed agitation giperglikemia.

Side-Effects

From the nervous system and sensory organs : irritability, anxiety, headache, the Sna.so part of the intestine : nausea, rarely vomiting, unpleasant feelings in epigastralna Oblasti.prochie : hyperemia person.

Precautions

To avoid any disruption of sleep last dose should be taken no later than 16 hours The treatment should follow a diet rich in carbohydrates.

Dosing and Administration

Inside, the food. Usually, the 0.25 g 2-3 times a day (no more than 2 g / day) for 10-15-30 days or after 3-5 days in a row at intervals 2-5 days (2-3 short course). If you like, you can repeat the scheme after one month. For the short-term efficiency of 0.25 g for 60 min before the work could re-tricks every four hours For long-term maintenance of a high level of efficiency on the 0.25 grams twice a day 5-dnevnami cycles with 2-dnevnami breaks from the courses.

Literature

Boiko SS, Bobkov Yu, Kuol GG, Serebrakov TV Pharmacokinetics and clinical effect bemitila after a single применения//Фармаколо гия and toxicology-1986 - N 5 .- C. 17-21.

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