Gamma-amino-beta-phenylbutirate hydrochloride

Chemical name

гамма-Амино-бета-фени��масляной acid hydrochloride

Gross

C10-H14-Cl-N-O2.H-Cl

Characteristics

The white crystalline powder. Very easily soluble in water, soluble in alcohol, pH water (2.5%) 2.3 solution. The chemical structure can be seen as derivative fenilnoe GABA, as well as a derivative fenilatilamina.

Of drugs

Drugs, the properties, anxiolytic. Impact on Gamk-retseptora in CNS facilitates Gamkergicescuu transfer pulses improves atherosclerosis processes in the brain. Alleviate tension, anxiety, anxiety, fear and improves sleep; Prolongs and enhances the psychological and neirolepticakih of narcotic analgesics. Decreases of fear and vazovegetativee symptoms (including headache, a feeling of gravity in the head, insomniu, irritability, emotional lability), improves mental fitness; Improves attention, memory, speed and accuracy senso-motornah reactions. In losing improves fitness enhances interest and motivation activities. Cutting latency period and reduces the duration and severity of Nistagma.absorbece stomach-high, well penetrates into all tissue and the GEB (in the tissue of the brain found about 0.1% rate imposed, people young and old, much more). Predominantly metabolized in the liver (80-95%) to pharmacologically active metabolites. About 5% excreted in the urine in an unmodified form. Not koumouliruet.

Indications

Asteniceski syndrome, тревожно-невротическ��е state (of concern, anxiety, fear), neurosis, obsessions conditions, sleeping, psihopatia, premedikation before surgical interventions, otogenny labirintit, vestibular human infection, and vascular traumatic genesis, including Ménière disease, dizziness, alcohol withdrawal syndrome (composed of combination therapy), the prevention of motion sickness in kinetozah; children - Chechnya, tools enourez.

Restrictions on the use of

Erosivno-yazvennoe defeated syndrome, pregnancy, breast-feeding.

Pregnancy and lactation

The caution (not enough clinical experience). In experimental studies have been found mutagennogo, tertogennogo and embriotoksicski action.

Contraindications

Гиперчувствительност ь.

Side-Effects

Drowsiness, nausea (with the first receptions), allergic reactions, gepatotoksicnosti (with a long reception of large doses 7-14 g).

Specific guidance

Weak after taking motion events (nausea, dizziness, etc.).

Patient interaction

Enhance and prolong the effect of tranquilizers and противопаркинсоничес ких funds doses and narcotic analgesics.

Overdosing

Symptoms : drowsiness, nausea, vomiting, muscular dystrophy liver (reception more than 7 grams), eozinofilia Arterial gipotenzia violation of Pocek.lechenie : symptomatic therapy.

Precautions

If long-term use is necessary control functions of the liver and peripheral Krovi.s use caution during the drivers of vehicles and people skills relate to the high concentration of attention.

Dosing and Administration

Inside, and food. Adults, on 0.25 g three times daily, if necessary, to 2.5 grams per day, the course of 2-3 weeks. Patients over 60 years of age is not more than 0.5 g per reception. For children up to 8 years in the 0,05-0,01 g 8-14 years - 0.25 g three times a day. The highest single dose : adults 0.75 g older patients - 0.5 g, children up to 8 years - 0.15 g, 8-14 years, 0.25 and severe alcohol withdrawal syndrome : in the first days of treatment for 0.25 g three times a day and 0.75 at night, with a gradual reduction of dose and the standard for adults. Otogenny labirintit and Ménière disease at a time of increased : 0.75 g 3-4 times a day for 5-7 days, continue to reduce symptoms vestibular disorders at 0.25 g three times a day for 5-7 days and then on the 0.25 g / day for 5 days. For minor illnesses, to 0.25 grams twice a day for 5-7 days, and the once a day for 7 to 10 days. Vertigo with vestibular dysfunction analyzer vascular and traumatic genesis : 0.25 g three times a day, 12 days. Preventing sickness : 0.25 g once for one hour before the trip.

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