Gamma-aminobutyric acid

Chemical name

4-aminobutanova acid

Gross

C4-H9-N-O2

Characteristics

The white crystalline powder with little bitter taste and unique flavour. Easily soluble in water, poor in spirit; PH 5% aqueous 6.5-7.5.

Of drugs

The drugs-stimulating metabolism in the central nervous system, properties. He is the main mediator involved in the central braking. Improves blood brain activates energy processes, improves the respiratory tissue activity, improves glucose utilization and disposal of toxic products exchange. Interacts with specific receptors Gamkergicakimi A and B types. Improves brain development processes in the brain, increases the productivity of thinking, memory, is a moderate psihostimulirutee, antihypoxia and protivosudorozhnoe действие.Способствуе�� Restoration voice and motor functions of the cerebral circulation. Provides moderate gipotenzivne action reduces initially increased AD and the severity of hypertension symptoms (dizziness, insomnia), slightly urejaet curves. The diabetics reduces glucose in the blood, in normal glycemia frequently leads giperglikemia due гликогенолизом.Конце��трация plasma reaches a peak after 60 min, and then declined rapidly; 24 hrs in plasma is not defined. Using the experimental data, poorly crosses the GEB. Malotoksicen.

Indications

The defeat cerebrovascular (arteriosclerosis, hypertension, etc.), cerebrovascular insufficiency and discirkulatornaya encephalopathy, impaired memory, attention, speech, dizziness, headaches, the effects of stroke and brain trauma, alcohol encephalopathy, polinevrit alcohol, mental retardation in children, dementia, infant cerebral palsy, endogenic depression-dominated астеноипохондрически х phenomena and the difficulties of mental activity simptomokomplex motion (sea and air sickness).

Pregnancy and lactation

Contraindicated in the first trimester of pregnancy.

Contraindications

Hypersensitivity, the children's age (up to 1 year), acute renal failure, pregnancy (I term).

Side-Effects

Nausea, vomiting, insomnia, fluctuations AD (in the early days of treatment), neuralgia, hyperthermia, a sense of heat.

Patient interaction

Enhance the effect of drugs that enhance the central nervous system. Benzodiazepines potenziruut effect.

Dosing and Administration

Inside, and food. Adults - 1,5-3,75 g / day, children 1-3 years of 0.5-2.0 g / day, 4-6 years, 2-3 g / day over 7 years to 3 g / sut. Daily dose is divided into three reception; Course, from 2-3 weeks to 2-4 Mes.sindrom motion : adult - 0.5 g, children - 0.25 g three times a day for three days; For the prevention, in the same dose over the three days preceding the possibility of sickness.

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